邵园,王建,梁炜,张迎黎,侯刚强,李霞,邢怡,王露,唐诗,王永军.老年睡眠障碍的重复经颅磁刺激精准干预专家共识[J].四川精神卫生杂志,2026,(2):97-105.Shao Yuan,Wang Jian,Liang Wei,Zhang Yingli,Hou Gangqiang,Li Xia,Xing Yi,Wang Lu,Tang Shi,Wang Yongjun,Expert consensus on precise intervention with repetitive transcranial magnetic stimulation for sleep disorders in the elderly[J].SICHUAN MENTAL HEALTH,2026,(2):97-105
老年睡眠障碍的重复经颅磁刺激精准干预专家共识
Expert consensus on precise intervention with repetitive transcranial magnetic stimulation for sleep disorders in the elderly
投稿时间:2026-03-06  
DOI:10.11886/scjsws20260306001
中文关键词:  老年  睡眠障碍  重复经颅磁刺激  抑郁障碍  轻度认知障碍  阿尔茨海默病
英文关键词:The elderly  Sleep disorders  Repetitive transcranial magnetic stimulation  Depression disorder  Mild cognitive impairment  Alzheimer's disease
基金项目:国家重点研发计划(项目名称:衰老过程心理-睡眠-认知相互作用机理及干预研究,项目编号:2023YFC3603200);深圳市科技创新局基础研究面上项目(项目名称:老年睡眠障碍的时空图神经网络(STGNN)机制研究,项目编号:JCYJ20240813112859008;项目名称:生物节律介导的脑类淋巴系统功能紊乱在抑郁症发病机制中的研究,项目编号:JCYJ20240813112900002);市康宁医院院级科研项目-青年项目(项目名称:光生物节律调控在AD治疗中的作用及其机制研究,项目编号:KN2023A004)
作者单位邮编
邵园 1深圳市康宁医院,深圳市精神卫生中心,广东 深圳 518118 518118
王建 1深圳市康宁医院,深圳市精神卫生中心,广东 深圳 518118 518118
梁炜 1深圳市康宁医院,深圳市精神卫生中心,广东 深圳 518118 518118
张迎黎 1深圳市康宁医院,深圳市精神卫生中心,广东 深圳 518118 518118
侯刚强 1深圳市康宁医院,深圳市精神卫生中心,广东 深圳 518118 518118
李霞 2上海交通大学医学院附属精神卫生中心,上海 200030 200030
邢怡 3首都医科大学宣武医院,北京 100053 100053
王露 4复旦大学基础医学院,上海 200032 200032
唐诗 5山东省立医院,山东 济南 250021 250021
王永军* 1深圳市康宁医院,深圳市精神卫生中心,广东 深圳 518118 518118
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中文摘要:
      近年来,重复经颅磁刺激(rTMS)在老年睡眠障碍的治疗中备受关注。然而,现有rTMS治疗方案多基于年轻患者的数据,尚缺乏针对老年人脑结构特征的精准化参数。本共识整合2010年—2025年循证医学证据,制定了适用于老年睡眠障碍患者的rTMS精准干预方案。共识制定组严格遵循临床指南研究与评估工具II(AGREE II)标准,系统检索关于rTMS治疗不同疾病相关睡眠障碍的随机对照试验(RCT)与系统评价。采用证据推荐分级的评估、制订与评价(GRADE)系统对证据质量和推荐强度进行分级。明确了老年睡眠障碍rTMS治疗的精准化策略,强调必须基于头皮-皮层距离进行强度校正,推荐使用磁共振导航或Beam F3/F4算法进行定位。本共识为老年睡眠障碍的rTMS治疗提供了精准干预方案,旨在提升临床疗效并保障患者的治疗安全。
英文摘要:
      In recent years, repetitive transcranial magnetic stimulation (rTMS) has garnered significant attention as a therapeutic approach for sleep disorders in the elderly. However, the prevailing rTMS protocols are predominantly developed based on normative neurophysiological data derived from young adults and fail to incorporate individualized parameters tailored to the brain characteristics of the elderly. To address this gap, the consensus development group synthesized the latest evidence from 2010 to 2025 and established a standardized rTMS protocol specifically for elderly patients with sleep disorders. Adhering to the Appraisal of Guidelines for Research and Evaluation II (AGREE II) framework, systematically screened randomized controlled trials (RCTs) and systematic reviews regarding rTMS in the treatment of sleep disorders across various conditions. Meanwhile, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was employed to rigorously grade the quality of evidence and the strength of recommendations. This consensus guideline delineates precise rTMS protocols for the management of sleep disorders in the elderly, highlights the adjustment of stimulation intensity according to scalp-cortex distance recommends either MRI-guided neuronavigation or the Beam F3/F4 heuristic approach for accurate target localization, thereby providing precise rTMS intervention protocol for sleep disorders in the elderly, aiming to enhance clinical efficacy while ensuring treatment safety. [Funded by National Key Research and Development Program (number, 2023YFC3603200); General Program of Shenzhen Science and Technology Innovation Commission (number, JCYJ20240813112859008, JCYJ20240813112900002); Youth Program of Shenzhen Kangning Hospital (number, KN2023A004); www.guidelines-registry.cn number, PREPARE-2026CN530]
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