杨颖,徐海婷,潘伟刚,徐鑫鹏,刘思源,李晓虹.额叶脑电图在青少年情绪障碍患者焦虑抑郁情绪和睡眠质量评估中的应用[J].四川精神卫生杂志,2026,(2):112-118.Yang Ying,Xu Haiting,Pan Weigang,Xu Xinpeng,Liu Siyuan,Li Xiaohong,Application of frontal electroencephalogram in assessment of anxiety, depression,and sleep quality in adolescents with emotional disorders[J].SICHUAN MENTAL HEALTH,2026,(2):112-118
额叶脑电图在青少年情绪障碍患者焦虑抑郁情绪和睡眠质量评估中的应用
Application of frontal electroencephalogram in assessment of anxiety, depression,and sleep quality in adolescents with emotional disorders
投稿时间:2025-09-10  
DOI:10.11886/scjsws20250910002
中文关键词:  青少年  情绪障碍  额叶脑电图  焦虑  抑郁  睡眠质量
英文关键词:Adolescents  Emotional disorders  Frontal electroencephalography  Anxiety  Depression  Sleep quality
基金项目:北京高层次创新创业人才支持计划(项目名称:“首都高端领军人才聚集培养工程”,项目编号:202504841041);横向联合课题(项目名称:基于耳部-额叶脑电图(ear-EEG)的大数据分析对于情绪障碍分级评估)
作者单位邮编
杨颖 1首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心, 精神疾病诊断与治疗北京市重点实验室,北京 100088 100088
徐海婷 2首都医科大学附属北京回龙观医院,北京 100096 100096
潘伟刚 2首都医科大学附属北京回龙观医院,北京 100096 100096
徐鑫鹏 2首都医科大学附属北京回龙观医院,北京 100096 100096
刘思源 1首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心, 精神疾病诊断与治疗北京市重点实验室,北京 100088 100088
李晓虹* 2首都医科大学附属北京回龙观医院,北京 100096 100096
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中文摘要:
      背景 近年来,青少年情绪障碍日益受到关注,而目前对情绪障碍的临床评估主要依赖访谈与量表,存在主观性较强、易受回忆偏倚影响等局限,亟须开发客观、可量化的辅助工具。额叶脑电图在既往研究中展现出评估抑郁、焦虑情绪的重要价值,但缺少标准化定量指标及直观可视化呈现,临床解读及患者接受程度有待提升。本研究将额叶脑电信号转化为定量可视化指标,以提高临床理解性与患者的接受程度。目的 探究额叶脑电图在评估青少年情绪障碍患者焦虑抑郁和睡眠质量中的价值,以期为临床诊断评估青少年情绪障碍提供客观辅助工具。方法 采用横断面设计,连续纳入2023年4月—2024年4月在北京某精神专科医院门诊就诊、符合《国际疾病分类(第10版)》(ICD-10)心境(情感)障碍、焦虑障碍诊断标准的12~18岁青少年患者105例。使用基于大数据分析的额叶脑电图收集脑电信号,并通过脑电系统将数据转化为6项定量脑功能指标:大脑负荷、紧张兴奋、情绪压力、困倦指数、大脑活力和大脑疲劳。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)和匹兹堡睡眠质量指数量表(PSQI)分别评定焦虑、抑郁情绪和睡眠质量。结果 青少年情绪障碍患者SAS评分与大脑负荷(rs=0.328,P<0.01)、情绪压力(rs=0.341,P<0.01)及大脑疲劳(rs=0.286,P<0.01)均呈正相关;SDS评分与大脑负荷(rs=0.275,P<0.01)、情绪压力(rs=0.241,P<0.05)及大脑疲劳(rs=0.311,P<0.01)呈正相关,与大脑活力呈负相关(rs=-0.212,P<0.05);PSQI总评分与大脑负荷(rs=0.340,P<0.01)、情绪压力(rs=0.322,P<0.01)及大脑疲劳(rs=0.229,P<0.05)均呈正相关。结论 额叶EEG中的大脑负荷、情绪压力、大脑疲劳和大脑活力指标可能有助于反映青少年情绪障碍患者的焦虑抑郁水平和睡眠质量。
英文摘要:
      Background Emotional disorders in adolescents have emerged as a prominent issue in recent years. Current mainstream clinical assessment approaches for such conditions predominantly rely on interviews and rating scales, which are limited by inherent drawbacks such as high subjectivity and recall bias. Accordingly, there exists an urgent clinical need for the development of objective, quantifiable auxiliary diagnostic tools.In previous studies, frontal electroencephalography (EEG) has demonstrated significant value in assessing depressive and anxiety. However, the lack of standardized quantitative metrics and intuitive visual analytical approaches has severely restricted clinical interpretability of EEG data and diminished patient engagement. To address these key limitations, the present study proposes an innovative analytical framework that converts frontal EEG signals into quantifiable visual metrics to enhance clinical comprehension and acceptance.Objective To explore the value of frontal EEG in assessing anxiety, depression, and sleep quality in adolescents with emotional disorders, with the aim of providing objective auxiliary tools for clinical diagnosis and assessment of adolescents with emotional disorders.Methods This cross-sectional study recruited 105 adolescents aged 12-18 years who visited the outpatient department of a specialized mental hospital in Beijing from April 2023 to April 2024. All participants met the diagnostic criteria for mood (affective) disorders or anxiety disorders in the International Classification of Diseases, tenth edition (ICD-10). Frontal EEG signals were collected within a big data analytics-driven framework and further processed by EEG system to generate six quantitative cerebral function indices, namely brain load, tension and excitement, emotional stress, sleepiness index, cerebral vitality, and cerebral fatigue. In addition, validated standardized scales, including the Self-rating Anxiety Scale (SAS), the Self-rating Depression Scale (SDS), and the Pittsburgh Sleep Quality Index (PSQI), were administered for anxiety, depressive symptoms, and sleep quality, respectively.Results In adolescent patients with emotional disorders, the SAS score exhibited significant positive correlations with brain load (rs=0.328, P<0.01), emotional stress (rs=0.341, P<0.01), and cerebral fatigue (rs=0.286, P<0.01). The SDS score was positively correlated with brain load (rs=0.275, P<0.01), emotional stress (rs=0.241, P<0.05), and cerebral fatigue (rs=0.311, P<0.01), while showing a significant negative correlation with cerebral vitality (rs=-0.212, P<0.05). Additionally, the PSQI total score demonstrated positive correlations with brain load (rs=0.340, P<0.01), emotional stress (rs=0.322, P<0.01), and cerebral fatigue (rs=0.229, P<0.05).Conclusion Frontal EEG-derived indices, including brain load, emotional stress, cerebral fatigue and cerebral vitality, may serve as objective markers for reflecting anxiety, depression, and sleep quality in adolescents with emotional disorders. [Funded by Beijing High level Innovation and Entrepreneurship Talent Support Program (number, 202504841041); Horizontal Joint Project]
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