| 徐莉丝,代彩霞,万姝,刘曼,蔡清艳.早发型阿尔茨海默病合并抗NMDAR脑炎1例[J].四川精神卫生杂志,2026,(2):171-174.Xu Lisi,Dai Caixia,Wan Shu,Liu Man,Cai Qingyan,Early-onset Alzheimer's disease comorbid with anti-N-methyl-D-aspartate receptor encephalitis： a case report[J].SICHUAN MENTAL HEALTH,2026,(2):171-174 |
| 早发型阿尔茨海默病合并抗NMDAR脑炎1例 |
| Early-onset Alzheimer's disease comorbid with anti-N-methyl-D-aspartate receptor encephalitis： a case report |
| 投稿时间：2025-12-01 |
| DOI：10.11886/scjsws20251201001 |
| 中文关键词: 抗NMDAR脑炎 阿尔茨海默病 影像学检查 神经炎症 |
| 英文关键词:Anti-N-methyl-D-aspartate receptor encephalitis Alzheimer's disease Imaging manifestations Neuroinflammation |
| 基金项目:成都市医学科研课题（项目名称：基于静息态功能磁共振对伴妄想症状AD患者脑功能特征的探索性研究，项目编号：2024403） |
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| 中文摘要: |
| 本文报道了一例抗NMDAR脑炎共病早发型阿尔茨海默病（AD）的男性患者，该患者以情绪低落、幻觉妄想综合征、认知障碍为主要表现并收治于精神专科医院。经多学科会诊，以生物、病理标志物阳性而明确诊断，给予激素冲击治疗、精神科相关治疗后症状得以改善。结合国内外相关研究，本文对早发型AD和抗NMDAR脑炎的发病机制、临床表现进行了文献回顾，以增强精神科专科医师对此类患者的甄别能力、提高诊疗水平。 |
| 英文摘要: |
| This article reports a case of a male patient with anti-N-methyl-D-aspartate receptor （NMDAR） encephalitis comorbid with early-onset Alzheimer's disease （AD）. The patient presented with depression， hallucinations and delusions syndrome， and cognitive impairment， and was admitted to a psychiatric hospital. Through multidisciplinary consultation， the diagnosis was confirmed based on positive biological and pathological biomarkers. The patient's symptoms improved after receiving a therapeutic regimen comprising high-dose glucocorticoid therapy and psychiatric-related treatments. Based on relevant current research findings domestically and internationally， this article reviews the pathogenesis and clinical manifestations of early-onset AD and anti-NMDAR encephalitis， in order to enhance the discrimination ability of psychiatric specialists for such patients and improve the diagnosis and treatment level. ［Funded by Medical Research Project of Chengdu City （number， 2024403）］ |
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