| 赵香君,张永利,霍小宁,申希平,杨晓莉,谯喜荣,舒兴彤.有氧运动对老年双相情感障碍患者认知功能的影响[J].四川精神卫生杂志,2026,(3):206-211.Zhao Xiangjun,Zhang Yongli,Huo Xiaoning,Shen Xiping,Yang Xiaoli,Qiao Xirong,Shu Xingtong,Effects of aerobic exercise on cognitive function in elderly patients with bipolar disorder[J].SICHUAN MENTAL HEALTH,2026,(3):206-211 |
| 有氧运动对老年双相情感障碍患者认知功能的影响 |
| Effects of aerobic exercise on cognitive function in elderly patients with bipolar disorder |
| 投稿时间：2025-08-19 |
| DOI：10.11886/scjsws20250819001 |
| 中文关键词: 老年患者 双相情感障碍 有氧运动 认知功能 |
| 英文关键词:Elderly patients Bipolar disorder Aerobic exercise Cognitive function |
| 基金项目:甘肃省科技计划项目（项目名称：使用fNIRS技术探索兰州市老年MCI患者的脑功能特征与认知功能关联性研究；项目编号：24JRRA775）；兰州市科技计划项目（项目名称：有氧运动对老年恢复期双相情感障碍患者认知认知功能的影响；项目编号：2022-5-155） |
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| 中文摘要: |
| 背景 双相情感障碍是一种以躁狂与抑郁交替发作为特征的严重精神障碍，具有高复发率、高致残率的特点。老年患者因神经退行性改变，认知功能受损往往更严重。对双相情感障碍的临床干预以药物治疗为主，但药物对认知功能的改善作用有限，甚至部分药物可能加重认知障碍。有氧运动作为一种非药物干预手段，在精神疾病患者的认知功能改善方面展现出积极作用，然而，针对老年双相情感障碍患者的相关研究仍较缺乏。目的 探讨有氧运动对老年双相情感障碍患者认知功能的影响，为该群体认知功能改善策略的制定提供参考。方法 采用随机对照试验，选取2024年1月—2025年3月在兰州市第三人民医院住院、符合《国际疾病分类（第10版）》（ICD-10）双相情感障碍诊断标准的老年患者60例，按照随机数字表法分为研究组和对照组各30例。两组均接受富马酸喹硫平片和丙戊酸镁缓释片治疗，研究组在此基础上接受有氧运动（包括慢走、做操、跑步），每周3次、每次30 min。于基线期及干预第3、6、9、12周末，采用汉密尔顿抑郁量表24项版（HAMD-24）、杨氏躁狂评定量表（YMRS）、蒙特利尔认知评估量表（MoCA）以及中国修订韦氏记忆量表（WMS-RC）进行评定。结果 HAMD-24评分的时间效应有统计学意义（Wald χ2=124.564，P<0.01）；YMRS评分的时间效应有统计学意义（Wald χ2=145.608，P<0.01），时间与组别的交互效应有统计学意义（Wald χ2=14.968，P<0.05）。干预第3、9、12周末，研究组YMRS评分均低于同期对照组，差异均有统计学意义（P均<0.05）。MoCA评分的时间效应和组别效应均有统计学意义（F=99.347、16.623，P均<0.01）；WMS-RC记忆商数的时间效应、组别效应以及时间与组别的交互效应均有统计学意义（F=64.678、10.197、12.472，P均<0.01）。干预第6、9、12周末，研究组MoCA评分和WMS-RC记忆商数均高于对照组，差异均有统计学意义（P均<0.05）。结论 有氧运动可能有助于改善老年双相情感障碍患者的躁狂症状及认知功能，尤其是记忆能力。 |
| 英文摘要: |
| Background Bipolar disorder is a severe mental disorder characterized by alternating episodes of mania and depression. It has a high recurrence rate and a high rate of disability. Elderly patients often suffer from more severe cognitive impairment due to neurodegenerative changes. The clinical intervention for bipolar disorder mainly relies on drug treatment， but drugs have limited effects on improving cognitive function， and some drugs may even aggravate cognitive impairment. Aerobic exercise， as a non-drug intervention method， has shown positive effects in improving cognitive function in patients with mental disorders. However， there are still insufficient studies on elderly patients with bipolar disorder.Objective To explore the impact of aerobic exercise on the cognitive function of elderly patients with bipolar disorder， so as to provide references for the formulation of strategies to improve the cognitive function of this population.Methods A randomized controlled trial was conducted. A total of 60 elderly patients who were hospitalized at the Third People's Hospital of Lanzhou from January 2024 to March 2025 and met the diagnostic criteria for bipolar disorder as defined in the International Classification of Diseases，tenth edition （ICD-10） were selected. They were divided into the study group and the control group， with 30 cases in each group， based on the random number table method. Both groups were given quetiapine fumarate tablets and magnesium valproate sustained-release tablets. The study group additionally received aerobic exercise （including slow walking， doing exercises， and running）， three times a week， for 30 minutes each time. At the baseline and at the end of the 3rd， 6th， 9th， and 12th week of the intervention， the Hamilton Depression Scale -24 item （HAMD-24）， the Young Manic Rating Scale （YMRS）， the Montreal Cognitive Assessment （MoCA）， and Wechsler Adult Intelligence Scale Revised in China （WMS-RC） were used for assessment.Results The time effect of the HAMD-24 score was statistically significant （Wald χ2=124.564， P<0.01）. The time effect of the YMRS score was also statistically significant （Wald χ2=145.608， P<0.01）， and the interaction effect between time and group was statistically significant （Wald χ2=14.968， P<0.05）. At the 3rd， 9th， and 12th week of the intervention， the YMRS score of the study group was lower than that of the control group in the same period， and the differences were statistically significant （P<0.05）. The time effect and group effect of the MoCA score were both statistically significant （F=99.347， 16.623， P<0.01）. The time effect， group effect， and interaction effect between time and group of the WMS-RC memory quotient were all statistically significant （F=64.678， 10.197， 12.472， P<0.01）. At the 6th， 9th， and 12th weeks of the intervention， the MoCA score and WMS-RC memory quotient of the study group were higher than those of the control group， and the differences were statistically significant （P<0.05）.Conclusion Aerobic exercise may help improve the manic symptoms and cognitive functions （especially memory ability） of elderly patients with bipolar disorder. ［Funded by Science and Technology Project of Gansu Province （number， 24JRRA775）； Science and Technology Project of Lanzhou City（number， 2022-5-155）］ |
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