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| 无抽搐电休克治疗阿尔茨海默病2例 |
| Alzheimer's disease in two cases with modified electroconvulsive therapy |
| 投稿时间：2025-01-11 修订日期：2025-07-31 |
| DOI： |
| 中文关键词: 无抽搐电休克治疗 阿尔茨海默病 激越行为 精神分裂症 |
| 英文关键词:Modified electroconvulsive therapy Alzheimer's disease agitation Schizophrenia |
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| 中文摘要: |
| 阿尔茨海默病（AD）是一种常见的神经退行性疾病，除认知功能进行性衰退外，常伴随激越、攻击行为等行为障碍，而传统药物治疗（如抗精神病药）疗效有限且存在严重副作用。无抽搐电休克治疗（MECT）是一种改良的电休克疗法，广泛应用于精神疾病的治疗。本文报道了MECT对AD患者（19次MECT/2次住院周期）及精神分裂症共病AD患者（48次MECT/3次住院周期）激越、攻击行为障碍的疗效及耐受性。结合国内外相关研究，分析MECT在改善AD患者行为障碍方面的潜在作用，旨在为制定AD的MECT治疗方案提供临床参考。 |
| 英文摘要: |
| Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive cognitive deterioration, frequently accompanied by behavioral disturbances such as agitation and aggression. Conventional pharmaceutical treatments (e.g., antipsychotics) often demonstrate limited efficacy and significant adverse effects. Modified Electroconvulsive Therapy (MECT), an advanced form of electroconvulsive therapy, is widely used in the management of psychiatric disorders. This report details the efficacy and tolerability of MECT in alleviating agitation and aggression in an AD patient (19 MECT sessions over two hospitalizations) and a patient with schizophrenia comorbid with AD (48 MECT sessions over three hospitalizations). By integrating relevant research findings from domestic and international sources, we analyze the potential role of MECT in improving behavioral disturbances in AD patients. The aim is to provide clinical guidance for developing MECT treatment protocols for AD. |
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