| WANG Hua-yong,LI Kan-qian,MA Yuan-ye,To observe the efficacy of Mianserin in treatment of patients with first-episode depression[J].SICHUAN MENTAL HEALTH,2014,27(2):162-163 |
| To observe the efficacy of Mianserin in treatment of patients with first-episode depression |
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| English keywords:Mianserin Fluoxetine First-episode depression |
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| Objective To observe the efficacy and safety of Mianserin in treatment of patients with first-episode depression. Methods 128 patients with first-episode depression were randomly divided into Mianserin group （64 cases treated with Mianserin）and Fluoxetine group （64 cases treated with Fluoxetine）for 8 weeks.The efficacy was assessed with HAMD and HAMA,while the adverse reactions were assessed with TESS.Results The effective rate of mianserin group is 92.2%,the effective rate of fluoxetine group is 89.1%.There are no differences between the two groups （P〉0.05）.But the scores of HAMD and HAMA of Mianserin group were lower than those of Fluoxetine group （P〈0.05）.Conclusion Mianserin is faster response, less adverse reactions than fluoxetine.It can improve sleep and anxiety symptom in treatment of patients with first-episode depression. |
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