| WEN Lu,LI Bing-ling,MA Yong-chun,Prospective observation of switching rate of antidepressants in management of depressive episode in 3 months[J].SICHUAN MENTAL HEALTH,2015,28(1):1-3 |
| Prospective observation of switching rate of antidepressants in management of depressive episode in 3 months |
DOI：10.11886/j.issn.1007-3256.2015.01.001 |
| English keywords:Antidepressants Switching Mood Stabilizer Family History |
| Fund projects:国家中医药管理局中医心理学重点学科项目(国中医药人教发2012-32);浙江省中西医结合中医临床心理学项目(2012-XK-A02);浙江省卫生厅医药科研基金资助项目(2006A017);浙江省中西结合抑郁症重点专科项目(2007) |
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| Objective To observe prospectively of switching rate of antidepressants in management of depressive episode. Meth-ods 190 patients with depressive episode treated by antidepressants were observed for 3 months and switching rate were assessed under psychiatrist selection without limitation . Results ①18 of 190 patients was found to switch in 3 month therapy. The switching rate was 9. 47%. ②There is no significant difference in switching rate between the male and the female(6. 56%,10. 85%,χ2 =0. 89,P>0. 05).③There is no significant difference in switching rate between unipolar depression and bipolar depression(5. 88%,40%,χ2 =24. 29,P<0. 01).④ There is no significant difference in switching rate between patients token mood stabilizer and patients not token mood stabilizer(13. 8%,8. 44%,χ2 =1. 47,P>0. 05). ⑤There is no significant difference in switching rate between patients token more two antidepressants and patients token single antidepressant(12. 96%,8. 08%,χ2 =1. 07,P>0. 05). ⑥There is no significant difference in switching rate between patients with family history of mood disorder and patients without family history of mood disorder (18. 4%,7. 23%,χ2 =4. 43,P<0. 05).⑦The switching often carry out at one month after treatment with antidepressants. ⑧The sig-nificant difference in switching rate among various antidepressants were not found. Conclusion Some depressive patients may switch during treatment with antidepressant. |
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