| JIA Li-hong,WANG Wen-ke,LIU Jian-dong,Safety and effort of lithium carbonate and valproic acid magnesium with selective serotonin and switching[J].SICHUAN MENTAL HEALTH,2015,28(1):4-6 |
| Safety and effort of lithium carbonate and valproic acid magnesium with selective serotonin and switching |
DOI：10.11886/j.issn.1007-3256.2015.01.002 |
| English keywords:Mood stabilizers SSRIs Preventing switching Effects |
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| Objective To explore the effects of lithium carbonate and valproic acid salt in treatment and preventing switching of depression. Methods 120 outpatient and inpatient patients were recruited from May 2012 to April 2014 as the research object,which were randomly divided into two groups,both groups of patients were given SSRI antidepressants,group A were treated by SSRI joint lithium carbonate,group B were treated by SSRI joint magnesium valproate. All patients were assessed by HRSD and YMRS. Results The first week after the treatment,HRSD of both groups were decreased[Group A:(28. 5 ± 8. 2)vs.(23. 9 ± 7. 7),P<0. 05,Group B(27. 9 ± 7. 9)vs.(22. 9 ± 6. 9),P<0. 05],after 8 weeks treatment HRSD of both groups were decreased significantly[ Group A (28. 5 ± 8. 2)vs.(10. 1 ± 6. 2,P<0. 01),Group B(27. 9 ± 7. 9)vs.(29. 8 ± 5. 1),P<0. 01]. No statistical difference between the two groups was found. There is no statistical significance in effective rate and remission rate between two groups,(66. 1%,68. 9%,χ2=0. 11,P>0. 05;30. 6%vs. 31. 0%,P>0. 05). TESS was no difference between two groups[(2. 6 ± 1. 5)vs.(2. 5 ± 1. 4),P>0. 05]. No difference in switching rate was found(4. 8%vs. 6. 8%,P>0. 05). Conclusion Lithium carbonate and magnesium val-proate may have its beneficial aspects in therapeutic and preventing switching without difference in side effects. |
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