| ,Progress in the study of the correlation between ceramide and depression[J].SICHUAN MENTAL HEALTH,2019,32(1):74-77 |
| Progress in the study of the correlation between ceramide and depression |
DOI：10.11886/j.issn.1007-3256.2019.01.017 |
| English keywords:Ceramide Acid sphingomyelinase Depression |
| Fund projects:国家自然科学基金项目(81571334)；山东省自然科学基金(ZR2011HM023)；山东省研究生教育创新计划项目（SDYY15012)；山东省本科高校教学改革研究项目(2015M049) |
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| The etiology of depression has not been fully elucidated. There is an increasing evidence that ceramide is involved in cell survival, proliferation, differentiation, apoptosis and other basic life processes, which break through the previous view of inert lipid. At present, ceramide, as an active second messenger, may be an important link between central brain dysfunction, peripheral inflammation and oxidative stress in depression. However, the exact relationship between ceramide and depression is not clear. This paper reviewed the progress of ceramide and depression research, and provided a new idea to explore the etiology of depression. |
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