| ,Brain - derived neurotrophic factor level and neuronal apoptosis in first - episode schizophrenia in children[J].SICHUAN MENTAL HEALTH,2019,32(2):135-138 |
| Brain - derived neurotrophic factor level and neuronal apoptosis in first - episode schizophrenia in children |
DOI：10.11886/j.issn.1007-3256.2019.02.009 |
| English keywords:Brain - derived neurotrophic factor Schizophrenia Children Apoptosis Neurons |
| Fund projects:昆明市卫生和计划育委员会医药卫生科技项目(2018-03-09-004)；昆明市卫生科技人才培养项目暨"十百千"工程(2018-SW(后备人选)-89) |
|
| Hits: |
| Download times: |
| English abstract: |
| Objective To investigate the changes of the brain - derived neurotrophic factor ( BDNF) , class III β - tubulin( Tuj - 1 ) and Caspase - 3 levels in first - episode schizophrenic children, so as to provide references for revealing the etiology and pathogenesis of schizophrenia. Methods 35 cases of schizophrenic children ( study group) met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition ( DSM - IV) and 30 cases of healthy children ( control group) in the Second People's Hospital of Dali Prepecture from August 2015 to March 2018 were selected. Then the mRNA levels of BDNF, Caspase - 3 and Tuj - 1 were detected in both groups by quantitative polymerase chain reaction ( RT - PCR) . Results The study group had higher Caspase - 3 mRNA expression level ( P < 0. 01 ) as well as lower BDNF and Tuj - 1 ( P < 0. 05 or 0. 01 ) mRNA expression levels than those of the control group. Conclusion The BDNF and Tuj - 1 mRNA expression levels are down - regulated, meanwhile the Caspase - 3 mRNA expression level is up - regulated in schizophrenic children, indicating that the three indicators may be related to the onset of schizophrenia. |
| View Full Text
View/Add Comment Download reader |
| Close |