| ,Efficacy of low-frequency repetitive transcranial magnetic stimulation on anxiety, depression and relapse in alcohol dependence patients after acute withdrawal[J].SICHUAN MENTAL HEALTH,2019,32(4):342-345 |
| Efficacy of low-frequency repetitive transcranial magnetic stimulation on anxiety, depression and relapse in alcohol dependence patients after acute withdrawal |
DOI：10.11886/j.issn.1007-3256.2019.04.011 |
| English keywords:Low-frequency repetitive transcranial magnetic stimulation Alcohol-dependent Anxiety Depression Drinking relapse |
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| Objective To explore the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) on anxiety, depression and relapse after acute withdrawal of alcohol dependence patients, and to provide references for improving the prognosis of patients with alcohol dependence.Methods A total of 102 alcohol dependence inpatients from The Third Hospital of Mianyang who met the International Classification of Diseases, tenth edition (ICD-10) of alcohol dependence after acute withdrawal were enrolled, and divided into the study group (n=50) and control group (n=52) by random number table method. Both groups received conventional treatment, and the study group received rTMS, while the control group received Sham rTMS. During 8 weeks of continuous treatment,patients were assessed by Hamilton Depression Scale-17 item (HAMD-17) and Hamilton Anxiety Scale (HAMA) at the 2nd, 4th and 8th weekend of treatment. After discharge, relapse was also assessed.Results Compared with those before treatment, HAMA and HAMD-17 scores at the 2nd, 4th and 8th weekend of treatment of the study group were decreased (P<0.01), and lower than those of the control group (P<0.01). At the end of the 3rd and 6th month after discharge, the relapse rate of study group were lower than those of the control group (P<0.05).Conclusion Low-frequency rTMS may ameliorate the anxiety, depression and relapse in patients with alcohol dependence after acute withdrawal. |
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