| Shen Zonglin,Cheng Yuqi,Lu Yi,Liu Fang,Lu Jin,Xu Xiufeng,Study of differences in brain functional connectivity between early and later onset depression among first-episode drug-naive adult patients[J].SICHUAN MENTAL HEALTH,2019,32(5):406-412 |
| Study of differences in brain functional connectivity between early and later onset depression among first-episode drug-naive adult patients |
DOI：10.11886/j.issn.1007-3256.2019.05.005 |
| English keywords:Major depressive disorder Magnetic resonance imaging Precuneus Functional connectivity Age at onset |
| Fund projects:国家自然科学基金（81660237）；云南省卫生内设研究机构项目（2018NS0109）；云南省应用基础研究2017FE468（-176） |
| Author Name | Affiliation | Postcode | | Shen Zonglin | First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | 650032 | | Cheng Yuqi | First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | 650032 | | Lu Yi | First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | 650032 | | Liu Fang | First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | 650032 | | Lu Jin | First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | 650032 | | Xu Xiufeng | First Affiliated Hospital of Kunming Medical University, Kunming 650032, China | 650032 |
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| Objective To compare the differences of functional connectivity (FC) of default mode network (DMN) between early onset depression (EOD) and later onset depression (LOD) adult patients, and to explore whether depression patients with different age of onset have different pathogenesis.Methods EOD patients (n=58) and LOD patients (n=62) from First Affiliated Hospital of Kunming Medical University were enrolled. Meanwhile, young healthy control group (n=60) and old healthy control group (n=52) were set as controls. Resting-state fMRI scan was performed on all selected subjects, and the left precuneus (PCu) was selected as the seed point to calculate the functional connectivity of whole brain, then the results among four groups were compared.Results Brain regions with different functional connectivity among four groups involved bilateral frontal lobe, temporal lobe, basal ganglia, occipital lobe, parietal lobe and cerebellum. Compared with the young healthy control group, the functional connectivity between the left precuneus and the Crus1 region of the left cerebellum, left cerebellum IX, left middle temporal gyrus, right precuneus, right anterior cingulate gyrus, right middle frontal gyrus, right angular gyrus, right insula, right medial superior frontal gyrus and the right middle temporal gyrus in the EOD group were all higher (Z=3.752 4~5.867 8, P<0.05), the functional connectivity between the left precuneus and the left middle frontal gyrus, left paracentral lobule, right superior marginal gyrus, right superior frontal gyrus, right inferior temporal gyrus, right posterior central gyrus, right anterior central gyrus and right superior occipital gyrus were all lower in the EOD group (Z=-5.007 6~-3.797 7, P<0.05). Compared with the old healthy control group, the left precuneus in LOD group had higher functional connectivity with the left cerebellum Crus2 area, left caudatus nucleus, left inferior temporal gyrus, left cerebellum Crus1 area, left angular gyrus, left middle frontal gyrus, right medial frontal gyrus, right angular gyrus and right orbitofrontal gyrus (Z=4.122 8~6.579 4, P<0.05), and lower functional connectivity was also found between left precuneus and the left parhippocampal gyrus, left superior frontal gyrus, right middle occipital gyrus, right anterior central gyrus, right medial superior frontal gyrus, right sawed gyrus, right inferior temporal gyrus, right paracentral lobule, right fusiform gyrus, and right posterior cingulate gyrus in LOD group (Z=-5.884 0~-3.617 2, P<0.05). Compared with the LOD group, the functional connectivity between the left precuneus and left saw-like gyrus, left cerebellar IV-VI region and the left cerebellar Crus2 region in the EOD group were higher (Z=4.087 7, 3.937 4, 3.672 1, P<0.05), and the functional connectivity between the left precuneus and right middle frontal gyrus, right orbital inferior frontal gyrus and right superior frontal gyrus were lower (Z=-4.274 8, -3.956 8, -4.724 3, -3.663 2, P<0.05).Conclusion Increased FC within DMN and decreased FC in frontoparietal network (FPN) may associated with the pathological mechanism of EOD, while increased FC in anterior of DMN and decreased FC in posterior of DMN may associated with the pathological mechanism of LOD, suggesting depressed adult patients with different age at onset might have different pathological mechanism. |
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