Yang Jing,Cheng Yuqi,Jiang Hongyan,Luo Xiongjian,Chen Xianyu,Shen Zonglin,Zhou Cong,Xu Xiufeng,Association between single nucleotide polymorphisms ofGRIA1, GRM3, TCF4 genes and schizophrenia[J].SICHUAN MENTAL HEALTH,2019,32(6):501-505

Association between single nucleotide polymorphisms ofGRIA1, GRM3, TCF4 genes and schizophrenia

DOI：10.11886/scjsws20190326001

English keywords:Schizophrenia GRIA1 GRM3 TCF4 Single nucleotide polymorphisms

Fund projects:国家自然科学基金 81660237 ; 云南省应用基础研究（昆医联合专项）[2017FE468（-176）] ; 昆明医科大学第一附属医院重大精神疾病研究省创新团队 2017HC004 国家自然科学基金(81660237)；云南省应用基础研究（昆医联合专项）[2017FE468（-176）]；昆明医科大学第一附属医院重大精神疾病研究省创新团队（2017HC004）

Author Name	Affiliation
Yang Jing	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
Cheng Yuqi	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
Jiang Hongyan	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
Luo Xiongjian	Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650000, China
Chen Xianyu	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
Shen Zonglin	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
Zhou Cong	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
Xu Xiufeng	The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China

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English abstract:

Objective To explore the relationships between three candidate functional genes (GRIA1, GRM3 and TCF4) and schizophrenia, and to provide references for genetic research of schizophrenia. Methods A total of 663 schizophrenia patients in the psychiatry department of the First Affiliated Hospital of Kunming Medical University who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) were selected as the research group, meanwhile, 690 healthy individuals in the physical examination center of the First Hospital of Kunming were set as the control group. 12 single nucleotide polymorphisms (SNPs) of three candidate functional genes were genotyped by the SNaPshot assay, and the genetic analysis was also performed. Results The A allele frequency of GRM3 SNP rs6465084 in the research group was significantly different from that of the control group (P=0.027). Gender-specific correlation analysis revealed that A allele frequency of SNP rs6465084 had statistic difference between male patients in research group and control group (P=0.02). Conclusion The SNP rs6465084 of GRM3 may be associated with the schizophrenia, and its A allele may increase the risk of schizophrenia.

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