Ge Xiangli,Li Huijing,Cui Minghu,Dong Yingying,Efficacy and safety of escitalopram combined with olanzapinein the treatment of depression: a Meta-analysis[J].SICHUAN MENTAL HEALTH,2019,32(6):523-530

Efficacy and safety of escitalopram combined with olanzapinein the treatment of depression: a Meta-analysis

DOI：10.11886/scjsws20190903001

English keywords:Escitalopram Olanzapine Depression Meta-analysis

Fund projects:

Author Name	Affiliation
Ge Xiangli	Clinical Medical College of Binzhou Medical University, Binzhou Medical University Hospital, Binzhou　 256600, China
Li Huijing	Clinical Medical College of Binzhou Medical University, Binzhou Medical University Hospital, Binzhou　 256600, China
Cui Minghu	Clinical Medical College of Binzhou Medical University, Binzhou Medical University Hospital, Binzhou　 256600, China
Dong Yingying	Clinical Medical College of Binzhou Medical University, Binzhou Medical University Hospital, Binzhou　 256600, China

Hits:

Download times:

English abstract:

Objective To evaluate the efficacy and safety of escitalopram combined with olanzapine in the treatment of depression, so as to provide references for the selection of treatment programs for depression. Methods Randomized controlled trials (RCTs) about the treatment published in foreign and domestic databases, including CNKI, Wanfang Data, VIP database, Duxiu database, China Biology Medicine database (CBM), PubMed, Web Of Science and Cochrane Library were retrieved. After screening the literature according to inclusion and exclusion criteria, extracting the data and evaluating the risk of bias, Revman 5.3 was used for Meta-analysis. Results A total of 16 RCTs involving 1 300 patients were included. The results of Meta-analysis showed that the final effective rate (RR=1.16, 95% CI: 1.05~1.28, P=0.004) and final healing rate (RR=1.91, 95% CI: 1.58~2.31, P<0.01) of the escitalopram combined with olanzapine group and the escitalopram group alone were statistically significant. After treatment for 4 weeks (SMD=-0.95, 95% CI: -1.28~-0.62, P<0.01) and 8 weeks (SMD=-1.53, 95% CI: -1.84~-1.22, P<0.01), the differences in HAMD scores between the two groups were statistically significant. The incidence of weight gain (RR=6.21, 95% CI: 3.37~11.45, P<0.01) and drowsiness (RR=4.26, 95% CI: 2.17~8.36, P<0.01) of escitalopram combined with olanzapine group were higher than those of the escitalopram group alone. Conclusion Escitalopram combined with olanzapine may have a better efficacy on depression than escitalopram monotherapy, but combination therapy may result in increased weight gain and drowsiness.

View Full Text View/Add Comment Download reader