| Yang Bin,Jiang Feng,Pan Miao,Wang Qi,Zhang Xue,Guo Shilong,Guo Xinsheng,Zhang Ruiling,Retrospective study of thyroid function in patients with bipolar disorder at different status[J].SICHUAN MENTAL HEALTH,2020,33(3):231-235 |
| Retrospective study of thyroid function in patients with bipolar disorder at different status |
DOI：10.11886/scjsws20200115001 |
| English keywords:Bipolar mania Bipolar depression Thyroid function Gender |
| Fund projects:国家自然科学基金资助项目（项目名称：NR2B基因组蛋白乙酰化调控与酒依赖及戒断的关系研究，项目编号：81471351；项目名称：MicroRNA-mRNA负调控网络对wistar大鼠酒依赖行为表征的调控作用及机制研究，项目编号：U1804170） |
| Author Name | Affiliation | Postcode | | Yang Bin | The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang 453002, China
Henan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang 453002, China
Henan Clinical Medical Research Center of Mental and Psychological Diseases, Xinxiang 453002, China | 453002 | | Jiang Feng | The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang 453002, China | 453002 | | Pan Miao | The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang 453002, China | 453002 | | Wang Qi | The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang 453002, China
Henan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang 453002, China
Henan Clinical Medical Research Center of Mental and Psychological Diseases, Xinxiang 453002, China | 453002 | | Zhang Xue | The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, China | 453000 | | Guo Shilong | The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, China | 453000 | | Guo Xinsheng | The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang 453002, China
Henan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang 453002, China
Henan Clinical Medical Research Center of Mental and Psychological Diseases, Xinxiang 453002, China | 453002 | | Zhang Ruiling | The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang 453002, China
Henan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang 453002, China
Henan Clinical Medical Research Center of Mental and Psychological Diseases, Xinxiang 453002, China | 453002 |
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| Objective To explore the thyroid function in patients with bipolar disorder of different clinical phases and genders, and to provide references for clinical diagnosis and treatment.Methods A retrospective study was conducted to collect thyroid function biochemical indicators of hospitalized patients in Henan Mental Hospital from September 2015 to January 2018, including thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3) and free thyroxine (FT4). According to the diagnostic criteria of the International Classification of Diseases, tenth edition (ICD-10), a total of 2 207 patients with bipolar manic episode (bipolar mania) and bipolar depressive episode (bipolar depression) were enrolled, and 415 healthy physical examinees were set as normal control group. Then the thyroid function in patients with bipolar disorder of different clinical phases and different genders were compared.Results ①The levels of T3 and FT3 in bipolar mania patients were higher than those in bipolar depression patients, and the levels of TSH and T4 were lower than those in normal control group, the levels of TSH, T3, T4 and FT3 in bipolar depression patients were lower than those in normal control group (P<0.05 or 0.01). ②Among bipolar mania patients, T3, FT3 and FT4 levels of the male were higher than those of the female, while TSH and T4 levels were lower than those of the female. Among bipolar depression patients, T3, FT3 and FT4 levels of the male were higher than those of the female, and TSH level was lower than that of the female (P<0.05 or 0.01). ③Among male patients, the T3 and FT3 levels of bipolar mania patients were higher than those of bipolar depression patients, and the T3 levels of bipolar depression patients were lower than those of the normal control group (P<0.05 or 0.01). Among female patients, the T3 and FT3 levels of bipolar mania patients were higher than those of bipolar depression patients, and the levels of T3, T4 and FT3 in bipolar depression patients were lower than those of normal control group (P<0.05 or 0.01).Conclusion Thyroid function in patients with bipolar disorder may have clinical and gender differences. |
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