| Fan Ni,Luo Yayan,Zhang Jie,Ou Yufen,He Hongbo,Changes of serum TNF-α, IL-6 and IL-18 levels in depressive disorder patients before and after treatment[J].SICHUAN MENTAL HEALTH,2020,33(4):317-320 |
| Changes of serum TNF-α, IL-6 and IL-18 levels in depressive disorder patients before and after treatment |
DOI：10.11886/scjsws20200407001 |
| English keywords:Depressive disorder Cytokines TNF-α IL-6 IL-18 |
| Fund projects:广东省科技计划项目（项目名称：精神疾病生物样本库的建立及临床应用，项目编号：2019B030316001）；广州市科技计划项目创新平台建设计划重点实验室项目（项目名称：广州市精神疾病临床转化实验室，项目编号：201805010009）；广州医科大学附属脑科医院中医重大课题（项目名称：精神分裂症患者和抑郁症患者中医辨证分型与血清细胞因子水平变化的相关性，项目编号：HAZY2017002） |
| Author Name | Affiliation | Postcode | | Fan Ni | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou 510370, China | 510370 | | Luo Yayan | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou 510370, China | 510370 | | Zhang Jie | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou 510370, China | 510370 | | Ou Yufen | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou 510370, China | 510370 | | He Hongbo | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou 510370, China | 510370 |
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| Objective To investigate the changes of serum levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-18 (IL-18) in patients with depressive disorder before and after treatment, and to certify their roles in disease development.Methods A total of 48 inpatients with depressive disorder (patient group) who met the diagnostic criteria of the international Classification of Diseases, tenth edition (ICD-10) were enrolled, and 64 healthy individuals (control group) were also recruited. Venous blood samples of both groups were collected before and after treatment. Serum TNF-α, IL-6, and IL-18 levels of all selected subjects were detected by ELISA. Clinical data such as the previous hospitalization times, length of stay, course of disease, age of onset and clinical dosage were collected. Depression status of patients was assessed using Hamilton Depression Scale-17 item (HAMD-17).Results Before treatment, TNF-α and IL-6 levels in patient group were higher than those in control group [(3.40±1.46) pg/mL vs. (2.02±1.39) pg/mL, (2.54±0.69) pg/mL vs. (0.49±0.30) pg/mL, P<0.05], and serum IL-18 level was significantly lower than that in control group [(23.01±4.55) pg/mL vs. (35.31±5.20) pg/mL, P<0.05]. Serum levels of TNF-α, IL-6 and IL-18 showed no significant difference within patient group before and after treatment (P>0.05). The changes in TNF-α, IL-6 and IL-18 levels before and after treatment were not linearly correlated with previous hospitalization times, length of stay, course of disease, age of onset, clinical dosage and HAMD-17 score (P>0.05).Conclusion No significant correlation is found between the improvement of depressive symptoms and the changes of TNF-α, IL-6, and IL-18 concentrations. |
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