| Zhang Xiaoming,Cheng Yongpeng,Yang Peng,Shi Yajie,Dong Zaiquan,Hu Junmei,Zheng Zhong,Study of P50 sensory gating deficit in schizophrenic patients with violent and aggressive behaviors[J].SICHUAN MENTAL HEALTH,2021,34(4):332-335 |
| Study of P50 sensory gating deficit in schizophrenic patients with violent and aggressive behaviors |
DOI：10.11886/scjsws20210610001 |
| English keywords:Schizophrenia Violent or aggressive behaviors Sensory gating P50 auditory-evoked potential |
| Fund projects:山东省卫生和健康委员会项目（项目名称：伴有攻击或暴力行为的精神分裂症患者感觉门控电位P50研究，项目编号：2015WS0422）；济宁市科技局项目（项目名称：伴有攻击或暴力行为的精神分裂症患者事件相关电位研究，项目编号：2000-45） |
| Author Name | Affiliation | Postcode | | Zhang Xiaoming | The Phychiatric Hospital of Jining, Jining 272051, China | 272051 | | Cheng Yongpeng | Zhucheng Mental Health Center, Zhucheng 266200, China | 266200 | | Yang Peng | The Phychiatric Hospital of Jining, Jining 272051, China | 272051 | | Shi Yajie | The Phychiatric Hospital of Jining, Jining 272051, China | 272051 | | Dong Zaiquan | West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Hu Junmei | West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Zheng Zhong | West China Hospital, Sichuan University, Chengdu 610041, China | 610041 |
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| Objective To assess the specificity of P50 auditory-evoked potential in schizophrenic patients with violent and aggressive behaviors， so as to provide objective biological markers for predicting violent behaviors of schizophrenic patients.Methods A total of135 schizophrenic patients who met the diagnostic criteria of the International Classification of Diseases， tenth edition （ICD-10） were divided into aggressive group （n=70） and non-aggressive group （n=65） according to the assessment results of the Modified Overt Aggression Scale （MOAS）， meantime， another 60 healthy individuals matched for age and gender were set as healthy group. Then the P50 auditory-evoked potentials of all selected individuals were measured using EP/EMG system （MEB-9200， Nihon Kohden， Japan）.Results Amp S2 of the aggressive group was significantly higher than those of the non-aggressive group and healthy control group， with statistical differences ［（9.86±6.04）μV vs. （7.06±3.88）μV， P=0.004； （9.86±6.04）μV vs. （7.82±3.87）μV， P=0.031］. The proportion of S2/S1 ratio ≥0.5 was 72.88%， 43.86% and 30.00% in aggressive group， non-aggressive group and healthy group， which was the highest in aggressive group， with statistical differences （P<0.01）. The amplitude difference of P50 （S1-S2） of the aggressive group was lower than those of the non-aggressive group and the healthy control group， the differences were of statistical significance ［（4.35±9.39）μV vs.（9.89±8.48）μV， P=0.001； （4.35±9.39）μV vs.（13.42±9.81）μV， P<0.01］.Conclusion The violent and aggressive behaviors in schizophrenic patients may be related to the sensory gating deficit. |
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