Zheng Chaodun,Chen Yingmei,Tan Jiuwei,Liu Guoxiong,Cai Yinglian,Lan Xiaofeng,Zhou Yanling,Comparison of cognitive function in patients with treatment-resistant depression and drug-naive first-episode major depressive disorder[J].SICHUAN MENTAL HEALTH,2021,34(5):429-434

Comparison of cognitive function in patients with treatment-resistant depression and drug-naive first-episode major depressive disorder

DOI：10.11886/scjsws20210123001

English keywords:Major depressive disorder Treatment-resistant depression Cognitive function First-episode

Fund projects:国家自然科学基金（项目名称：BDNF介导海马神经重塑在氯胺酮治疗抑郁-疼痛共病种的作用研究，项目编号：81801343），广东基础与应用基础研究基金（项目名称：基于“犬尿酸-谷氨酸”通路探讨氯胺酮抗抑郁的作用机制，项目编号：2019A1515011366）

Author Name	Affiliation	Postcode
Zheng Chaodun	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370
Chen Yingmei	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370
Tan Jiuwei	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370
Liu Guoxiong	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370
Cai Yinglian	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370
Lan Xiaofeng	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370
Zhou Yanling	The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders， Guangzhou 510370， China	510370

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English abstract:

Objective To explore the differences of cognitive function in patients with treatment-resistant depression and drug-naive first-episode major depressive disorder， and to examine the relationship between severity of clinical symptoms and cognitive function， so as to provide references for prognosis improvement.Methods From November 2016 to December 2019， 119 patients with drug-naive first-episode major depressive disorder and 82 patients with treatment-resistant depression in a hospital in Guangzhou were enrolled， meantime， another 71 healthy individuals recruited from the community were set as healthy control group. Clinical symptoms were assessed using Hamilton Depression Scale-17 item （HAMD-17） and Hamilton Anxiety Scale （HAMA）. Cognitive domains， including speed of processing， working memory， verbal learning and memory， and visual learning and memory were measured with the MATRICS Consensus Cognitive Battery （MCCB）. Multiple covariance analysis was used to compare the differences in cognitive function among three groups. Thereafter， partial correlation analysis was performed within patient groups to explore the relationship of HAMD-17/HAMA score with the four dimensions of MCCB.Results The speed of processing， visual learning and memory scores of treatment-resistant depression group and drug-naive first-episode depression group were lower than those of healthy control group， and the working memory score of the treatment-resistant depression group was lower than that of the healthy control group， with statistical significance （P<0.05 or 0.01）. The speed of processing， visual learning and memory scores of treatment-resistant depression group were significantly lower than those of drug-naive first-episode depression group （P<0.05 or 0.01）. Partial correlation analysis within patient groups found that HAMD-17/HAMA total score had no correlation with the four dimensions of MCCB （P>0.05）.Conclusion Compared with drug-naive first-episode major depressive disorder patients and healthy controls， the impairments of speed of processing， visual learning and memory are more severe in patients with treatment-resistant depression. Moreover， the cognitive function impairment in patients with drug-naive first-episode major depressive disorder and treatment-resistant depression has no correlation with the severity of depressive and anxious symptoms.

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