Hai Fan,Zhang Baoqin,Qiao Jing,Zhang Jingfang,Duan Daping,Zhang Qiheng,Guo Yujie,Wang Ying,Li Benliang,Yang Shichang,Influencing factors of medication adherence in patients with severe mental disorders in Zhengzhou[J].SICHUAN MENTAL HEALTH,2022,35(6):531-536

Influencing factors of medication adherence in patients with severe mental disorders in Zhengzhou

DOI：10.11886/scjsws20220818002

English keywords:Severe mental disorders Medication adherence Influencing factors

Fund projects:河南省2020年重大传染病防控精神卫生与慢性病防治专项（项目名称：精神卫生与慢性病防治项目，项目编号：豫财社［2019］190号）

Author Name	Affiliation	Postcode
Hai Fan	The Eighth People's Hospital of Zhengzhou， Zhengzhou 450015， China The Second Affiliated Hospital of Xinxiang Medical University， Xinxiang 453002， China	453002
Zhang Baoqin	Zhengzhou Center for Disease Control and Prevention， Zhengzhou 450042， China	450042
Qiao Jing	The Eighth People's Hospital of Zhengzhou， Zhengzhou 450015， China The Second Affiliated Hospital of Xinxiang Medical University， Xinxiang 453002， China	453002
Zhang Jingfang	Zhengzhou Center for Disease Control and Prevention， Zhengzhou 450042， China	450042
Duan Daping	Zhengzhou Center for Disease Control and Prevention， Zhengzhou 450042， China	450042
Zhang Qiheng	Zhengzhou Center for Disease Control and Prevention， Zhengzhou 450042， China	450042
Guo Yujie	The Ninth People's Hospital of Zhengzhou， Zhengzhou 450053， China	450053
Wang Ying	Zhengzhou Center for Disease Control and Prevention， Zhengzhou 450042， China	450042
Li Benliang	Zhengzhou Center for Disease Control and Prevention， Zhengzhou 450042， China	450042
Yang Shichang^*	The Second Affiliated Hospital of Xinxiang Medical University， Xinxiang 453002， China	453002

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English abstract:

Objective To investigate the status and influencing factors of medication adherence in patients with severe mental disorders in Zhengzhou， so as to provide references for the formulation of prevention and treatment measures for severe mental disorders.Methods From March to June 2021， a stratified multistage cluster sampling method was applied to select 342 patients from the National Information System for Severe Mental Disorders in Zhengzhou. The general demographic data of patients were collected via self-designed questionnaire， and the medication status was investigated， then the influential factors were summarized. The differences in influential factors of medication adherence were compared between the medication adherence group and the medication non-adherence group. Thereafter， Logistic regression analysis was applied to explore the factors influencing medication adherence.Results A total of 320 patients were included in the final analysis， altogether 76.56% of patients （n=245） complied with medication. The differences between patients in the medication adherence group and those in the medication non-adherence group were statistically significant in terms of residence， occupation， and outpatient chronic disease reimbursement （χ²=14.015， 7.502， 13.106， P<0.05 or 0.01）. In the questionnaire of influential factors on medication adherence， there were statistically significant differences in the scores of lack of insight， stigma and drug-related factors between the two groups （Z=7.588， 2.379， 2.893， P<0.05 or 0.01）. Outpatient chronic disease reimbursement was a protective factor for medication adherence （OR=2.727， 95% CI： 1.320~5.634， P<0.01）， while rural residence （OR=0.465， 95% CI： 0.221~0.977， P<0.05） and lack of insight （OR=0.398， 95% CI： 0.286~0.553， P<0.01） were risk factors for medication adherence.Conclusion Patients with severe mental disorders in Zhengzhou have a high rate of medication adherence， moreover， the outpatient chronic disease reimbursement， lack of insight and residence may be influencing factors for medication adherence in patients with severe mental disorders.

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