| Zheng Caiji,Shen Xiaodan,Li Yuji,Pharmaceutical care for patient with schizophrenia combined with pulmonary tuberculosis： a case report[J].SICHUAN MENTAL HEALTH,2022,35(6):577-579 |
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| Pharmaceutical care for patient with schizophrenia combined with pulmonary tuberculosis： a case report |
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Zheng Caiji, Shen Xiaodan, Li Yuji
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Shenzhen Mental Health Center/ Shenzhen Kangning Hospital， Shenzhen 518020， China
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| Abstract:This paper reported a case of schizophrenia combined with pulmonary tuberculosis treated with clozapine in combination with rifampicin. Due to the induction of hepatic drug enzyme of rifampicin， plasma concentration of clozapine could not reach the effective concentration and the patient still had psychotic symptoms such as persecutory delusion. After discontinuation of rifampicin， plasma concentration of clozapine were in the effective concentration range and the patient's psychiatric symptoms improved. By analysing the therapeutic regimen for the patient with schizophrenia combined with pulmonary tuberculosis， this case suggested a possible interaction between clozapine and rifampin， and provided a reference for the treatment of this type of patients. |
| Key words: Schizophrenia Pulmonary tuberculosis Clozapine Rifampicin |
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