| Ye Xiaoying,Tao Weiqun,Zhang Qingqing,Yang Yingjia,Xie Xinhui,Yang Binrang,Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study[J].SICHUAN MENTAL HEALTH,2023,36(2):111-117 |
| Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study |
DOI：10.11886/scjsws20230218003 |
| English keywords:Schizophrenia Patients in long-term hospitalization Glucose metabolism Lipid metabolism Real-world study |
| Fund projects:广东省高水平临床重点专科（深圳市配套建设经费）资助项目（项目编号：SZGSP013） |
| Author Name | Affiliation | Postcode | | Ye Xiaoying | Shantou University Medical College, Shantou 515041, China
Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen 518020, China | 518020 | | Tao Weiqun | Shantou University Medical College, Shantou 515041, China
Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen 518020, China | 518020 | | Zhang Qingqing | Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen 518020, China | 518020 | | Yang Yingjia | Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen 518020, China | 518020 | | Xie Xinhui | Renmin Hospital of Wuhan University, Wuhan 430060, China | 430060 | | Yang Binrang* | Shenzhen Children's Hospital, Shenzhen 518034, China | 518034 |
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| English abstract: |
| Objective To picture the trajectory of changes in glucose and lipid metabolism among schizophrenic patients in long-term hospitalization.Methods A total of 109 inpatients of Shenzhen Kangning Hospital from 2014 to 2022， who were diagnosed with schizophrenia based on the International Classification of Diseases， tenth edition （ICD-10） criteria， were recruited as subjects. Real-world follow-up data on longitudinal glucose metabolism （fasting blood glucose， glycosylated hemoglobin， C-peptide） and lipid metabolism （triglycerides， low density lipoprotein， high density lipoprotein， total cholesterol） were observed. The frequency of visit was once a year， with a total of 9 visits over 8 years.Results In terms of glucose metabolism parameters， fasting blood glucose level decreased to 4.87 mmol/L at the 7th visit， lower than the baseline level （P<0.01）. Glycated hemoglobin level was 6.08% at the 9th visit， higher than the baseline level （P<0.05）. C-peptide level was 3.14 ng/mL at the 7th visit， higher than the baseline level （P<0.01）. As for the trajectory of lipid metabolism parameters， high-density lipoprotein level were significantly lower than baseline level at the second visit （P<0.01） and stayed basically stable thereafter. Total cholesterol levels at the last three visits were 4.06， 4.07 and 3.95 mmol/L， respectively， all lower than the baseline level （P<0.01）.Conclusion The changes of glycolipid metabolism parameters in long-term inpatients with schizophrenia were generally smooth during the 8-year follow-up period. |
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