Ye Xiaoying,Tao Weiqun,Zhang Qingqing,Yang Yingjia,Xie Xinhui,Yang Binrang,Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study[J].SICHUAN MENTAL HEALTH,2023,36(2):111-117

Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study

DOI：10.11886/scjsws20230218003

English keywords:Schizophrenia Patients in long-term hospitalization Glucose metabolism Lipid metabolism Real-world study

Fund projects:广东省高水平临床重点专科（深圳市配套建设经费）资助项目（项目编号：SZGSP013）

Author Name	Affiliation	Postcode
Ye Xiaoying	Shantou University Medical College， Shantou 515041， China Shenzhen Mental Health Center/Shenzhen Kangning Hospital， Shenzhen 518020， China	518020
Tao Weiqun	Shantou University Medical College， Shantou 515041， China Shenzhen Mental Health Center/Shenzhen Kangning Hospital， Shenzhen 518020， China	518020
Zhang Qingqing	Shenzhen Mental Health Center/Shenzhen Kangning Hospital， Shenzhen 518020， China	518020
Yang Yingjia	Shenzhen Mental Health Center/Shenzhen Kangning Hospital， Shenzhen 518020， China	518020
Xie Xinhui	Renmin Hospital of Wuhan University， Wuhan 430060， China	430060
Yang Binrang^*	Shenzhen Children's Hospital， Shenzhen 518034， China	518034

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English abstract:

Objective To picture the trajectory of changes in glucose and lipid metabolism among schizophrenic patients in long-term hospitalization.Methods A total of 109 inpatients of Shenzhen Kangning Hospital from 2014 to 2022， who were diagnosed with schizophrenia based on the International Classification of Diseases， tenth edition （ICD-10） criteria， were recruited as subjects. Real-world follow-up data on longitudinal glucose metabolism （fasting blood glucose， glycosylated hemoglobin， C-peptide） and lipid metabolism （triglycerides， low density lipoprotein， high density lipoprotein， total cholesterol） were observed. The frequency of visit was once a year， with a total of 9 visits over 8 years.Results In terms of glucose metabolism parameters， fasting blood glucose level decreased to 4.87 mmol/L at the 7^th visit， lower than the baseline level （P<0.01）. Glycated hemoglobin level was 6.08% at the 9^th visit， higher than the baseline level （P<0.05）. C-peptide level was 3.14 ng/mL at the 7^thvisit， higher than the baseline level （P<0.01）. As for the trajectory of lipid metabolism parameters， high-density lipoprotein level were significantly lower than baseline level at the second visit （P<0.01） and stayed basically stable thereafter. Total cholesterol levels at the last three visits were 4.06， 4.07 and 3.95 mmol/L， respectively， all lower than the baseline level （P<0.01）.Conclusion The changes of glycolipid metabolism parameters in long-term inpatients with schizophrenia were generally smooth during the 8-year follow-up period.

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