Sun Hongfang,Chen Ling,Zhang Jing,Wang Yan,Liu Hongshuang,Metacognition in relation to quality of life in patients with ovarian cancer: mediating role of fear of disease progression[J].SICHUAN MENTAL HEALTH,2023,36(6):532-537
Metacognition in relation to quality of life in patients with ovarian cancer: mediating role of fear of disease progression
DOI:10.11886/scjsws20230225001
English keywords:Ovarian cancer  Metacognition  Fear of disease progression  Quality of life  Mediating role
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Author NameAffiliationPostcode
Sun Hongfang Cangzhou People's Hospital Cangzhou 061000 China 061000
Chen Ling Cangzhou Medical College Cangzhou 061000 China 061000
Zhang Jing Cangzhou Medical College Cangzhou 061000 China 061000
Wang Yan Cangzhou Medical College Cangzhou 061000 China 061000
Liu Hongshuang Botou Hospital Cangzhou 062150 China 062150
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English abstract:
      Background Quality of life, as a major criterion for judging the clinical outcome of ovarian cancer patients, can be affected by adverse psychological symptoms of patients. Meanwhile, fear of disease progression, as a frequent psychological symptom among cancer survivors, is significantly influenced by metacognition, while there is a paucity of research into the specific correlation among the three in patients with ovarian cancer.Objective To explore the correlation among fear of disease progression, metacognition and quality of life in patients with ovarian cancer, and to test the role of fear of disease progression in the relationship between metacognition and quality of life, so as to provide references for improving the quality of life in patients with ovarian cancer.Methods A total of 135 patients with ovarian cancer hospitalized in Cangzhou People's Hospital of Hebei Province from January 2019 to December 2022 were selected. All subjects were requested to complete the Functional Assessment of Cancer Therapy-Ovarian Cancer (FACT-O), Fear of Progression Questionnaire-Short Form (FoP-Q-SF) and Metacognition Questionnaire (MCQ) to assess their quality of life, fear of disease progression and metacognitive level. Pearson correlation analysis was adopted to examine the correlation among the above scales. Process v3.5 macro program was utilized to determine the mediating effect of fear of disease progression on the relationship between metacognition and quality of life, and nonparametric Bootstrap with bias-correction was used to test the mediating effect.Results A total of 122 patients (90.37%) with ovarian cancer completed the effective questionnaire survey. Patients scored (90.52±17.13) on FACT-O, (68.52±16.31) on MCQ, and (37.72±8.91) on FoP-Q-SF. Pearson correlation analysis denoted that FoP-Q-SF score was negatively correlated with FACT-O score (r=-0.412, P<0.05) and positively correlated with MCQ score (r=0.241, P<0.05), and MCQ score was negatively correlated with FACT-O score (r=-0.453, P<0.05). Analysis demonstrated that the total effect of metacognition on quality of life was -0.298 (95% CI: -0.402~-0.186). The direct effect of metacognition on quality of life was -0.219 (95% CI: -0.504~-0.277), accounting for 73.49% of the total effect, and the indirect effect of metacognition on quality of life via fear of disease progression was -0.079 (95% CI: -0.162~-0.037), accounting for 26.51% of the total effect.Conclusion Quality of life is reduced in patients with ovarian cancer, and fear of disease progression plays a partial mediating role in the relationship between metacognition and quality of life.
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