Wang Cong,Zhu Cuizhen,Zhang Xueying,Gao Hua,Pan Zhongde,Cheng Jian,Yang Deying,Zheng Mingming,Zhang Xulai,Relationship between inflammatory factor levels with metabolism， verbal fluency and information processing function in hospitalized schizophrenia patients[J].SICHUAN MENTAL HEALTH,2024,37(4):323-329

Relationship between inflammatory factor levels with metabolism， verbal fluency and information processing function in hospitalized schizophrenia patients

DOI：10.11886/scjsws20230927002

English keywords:Schizophrenia Inflammatory factor Metabolic level Verbal fluency Information processing function

Fund projects:2022年安徽省重点研究与开发计划立项项目（项目名称：基于CaMKK2/AMPK信号通路改善肠道菌群紊乱引发的精神分裂症伴代谢综合征的应用机制，项目编号：2022e07020002）

Author Name	Affiliation	Postcode
Wang Cong	School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022
Zhu Cuizhen	School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022
Zhang Xueying	Suzhou Guangji Hospital, Suzhou 215008, China	215008
Gao Hua	Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022
Pan Zhongde	Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Expertise of the Ministry of Justice, Shanghai Forensic Service Platform, Shanghai 200063, China	200063
Cheng Jian	Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022
Yang Deying	Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022
Zheng Mingming	Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022
Zhang Xulai^*	School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China Affiliated Psychological Hospital of Anhui Medical University, The Fourth People's Hospital of Hefei, Hefei 230022, China	230022

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English abstract:

Background Schizophrenic patients have metabolic disorders， impaired language and information processing function. Inflammatory factors may play an important role in the occurrence and development of schizophrenia.Objective To explore the relationship of the inflammatory factor levels with metabolic levels， language fluency and information processing function in patients with schizophrenia， so as to provide references for clinical understanding of the neuropathological mechanisms of schizophrenia.Methods A total of 96 patients with schizophrenia were included in the study group， who were hospitalized in the Fourth People's Hospital of Hefei from January 2021 to December 2022 as well as met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） and Mini-International Neuropsychiatric Interview （MINI） 6.0 .Meanwhile， population who underwent physical examination at the same hospital were included in the control group （n=42）. A high-sensitivity multi factor electrochemiluminescence analyzer was used to detect the levels of inflammatory factors IL-4， IL-5， IL-7， IL-8， IL-10 and IL-13. A fully automated biochemical analyzer was used to detect the levels of metabolic indicators such as fasting blood glucose， triglycerides， high-density lipoprotein， apolipoprotein A， creatinine and urea nitrogen. Verbal fluency and information processing function of all participants were assessed by using Verbal Fluency Test （VFT） and Stroop Color Word Test （SCWT）.Results There were statistically significant differences in the levels of IL-4， IL-5， IL-7， IL-8， IL-10， IL-13 and IL-15 between the study group and the control group （P<0.05）. There were statistically significant differences in BMI， waist circumference， fasting blood glucose， triglycerides， high-density lipoprotein， urea nitrogen， apolipoprotein A and creatinine levels between the two groups （P<0.05）. The differences in the correct number of household appliances， animals， fruits， vegetables， names starting with "water" and "self" in VFT between the two groups were statistically significant （P<0.05）. The differences in point reaction time， character reaction time and character color reaction time in SCWT between the two groups were statistically significant （P<0.05）. Correlation analysis showed that except for creatinine levels， the levels of IL-4 and IL-5 in patients with schizophrenia were correlated with other indicators （P<0.05）. IL-7 levels were correlated with creatinine levels， household appliances， animals， fruits， correct number of names starting with "water" in VFT， point reaction time and word reaction time in SCWT （P<0.05）. IL-8 levels were correlated with triglyceride levels， household appliances， animals， fruits， vegetables， correct number of names starting with "water" and "self" in VFT and word reaction time in SCWT （P<0.05）. Except for creatinine levels and the correct number of names starting with "self"， IL-10 levels were correlated with all other indicators （P<0.05）. Except for creatinine and urea nitrogen levels， IL-13 levels were correlated with other indicators （P<0.05）.Conclusion The levels of inflammatory factors in patients with schizophrenia may be related to their metabolic levels， language fluency and information processing function. ［Funded by Anhui Province Key Research and Development Plan Project （number， 2022e07020002）］

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