Xie Hongcheng,Feng Shuangshuang,Wang Tingting,Liang Junfan,Ren Jiajun,Zhang Hongli,Lin Ziyuan,Wang Siru,Xiang Bo,Liu Kezhi,Efficacy of modified electroconvulsive therapy combined with medication in inpatient schizophrenia patients and urban-rural differences[J].SICHUAN MENTAL HEALTH,2024,37(6):497-501

Efficacy of modified electroconvulsive therapy combined with medication in inpatient schizophrenia patients and urban-rural differences

DOI：10.11886/scjsws20240530003

English keywords:Schizophrenia Modified electroconvulsive therapy Urban and rural areas

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Author Name	Affiliation	Postcode
Xie Hongcheng	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China Southwest Medical University, Luzhou 646000, China	646000
Feng Shuangshuang	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Wang Tingting	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Liang Junfan	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Ren Jiajun	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Zhang Hongli	Southwest Medical University, Luzhou 646000, China	646000
Lin Ziyuan	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Wang Siru	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Xiang Bo	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China	646000
Liu Kezhi^*	The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China Zigong Mental Health Center, Zigong 643020, China	643020

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English abstract:

Background Combination of antipsychotic drugs and modified electroconvulsive therapy （MECT） is currently a commonly used method for treating schizophrenia， but its efficacy varies among different patient groups.Objective To explore the therapeutic effects of MECT on schizophrenia patients living in different urban versus rural environments， so as to provide references for the selection of treatment plans based on patients' residence.Methods A total of 587 patients hospitalized at Luzhou Mental Health Center， Zigong Mental Health Center and Yibin Fourth People's Hospital from May 2018 to August 2022， who met the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5），were included in the study. Patients were divided into two groups： medication-only group （n=106） and MECT combined with medication group （n=481）. In MECT combined with medication group， 24 rural patients residing in urban areas were excluded， leaving the remaining patients divided into urban group （n=103） and rural group （n=354） based on their place of residence. Positive and Negative Syndrome Scale （PANSS） was used to assess the severity of symptoms. Clinical efficacy was evaluated using PANSS score reduction rate， and covariance analysis was used to compare the therapeutic effects of different patients.Results The differences of reduction rate of PANSS total score， positive symptom scale score and negative symptom scale score as well as treatment effectiveness rate between MECT combined with medication group and medication-only group were statistically significant （F=11.149， 12.111， 31.725， χ²=14.010， P<0.01）. Statistically significant differences were also observed in reduction rate of PANSS total score and positive symptom subscale score as well as treatment effectiveness rate between urban and rural patients in MECT combined with medication group （F=3.946， 4.523， χ²=4.033， P<0.05）.Conclusion The efficacy of MECT combined with medication may be superior to medication alone in the treatment of schizophrenia， and the combined therapy may be more effective in urban patients than that in rural patients， with potentially more pronounced improvements in positive symptoms.

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