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| 经颅交流电对抑郁障碍患者认知功能的影响 |
| The impact of transcranial alternating current stimulation on cognitive function in patients with depressive disordersLi Dan1, Xia Zhong2, Zhu Wenli2, Liang Dandan2, Miao Wenwen2, Song Chuanfu2* |
| 投稿时间：2025-01-07 修订日期：2025-05-27 |
| DOI： |
| 中文关键词: 经颅交流电，抑郁障碍，认知功能 |
| 英文关键词:Transcranial Alternating Current Stimulation, Depression, Cognitive Function |
| 基金项目:安徽省临床医学研究转化专项项目 |
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| 中文摘要: |
| 背景 认知功能与个体的生活质量和社会功能息息相关，而抑郁患者在临床症状缓解后仍有20%~35%的患者会存在一定程度上的认知功能损害，目前认为tACS治疗能够改善抑郁症状，对于能否改善认知功能尚存在争议。目的 探究经颅交流电刺激（tACS）治疗对抑郁障碍患者认知功能的改善程度。方法 本研究于2022年11月至2024年10月期间在芜湖市第四人民医院招募49例抑郁障碍患者，通过Excel随机分为研究组（n=23人）和对照组（n=26人）。两组均接受舍曲林常规治疗。研究组接受tACS刺激20分钟，每周5次，持续4周；对照组接受同参数tACS刺激30秒。使用汉密尔顿抑郁量表、汉密尔顿焦虑量表及认知成套测验在基线、4周及12周时评估其抑郁情绪、焦虑情绪及认知功能。结果 两组在性别、年龄、文化程度等一般资料上无显著差异。HAMD和HAMA量表在时间效应和交互效应均有统计学意义（F=260.43、248.08，P<0.001），HAMA在组间效应上有统计学意义（F=4.5，P<0.05），在第4、12周时，研究组HAMA得分均小于对照组（P<0.05），HAMD在第12周时研究组得分小于对照组（P<0.01），且得分均低于基线（P<0.01）；两组在信息处理加工速度、注意/警觉性、工作记忆、词语学习、视觉学习、问题解决和总分的时间效应均有统计学意义（F=58.04、70.33、13.61、27.88、9.06、8.15、2.78、51.67，P均<0.01）；信息处理加工速度、注意/警觉性、词语学习、视觉学习、问题解决和总分的组间效应均有统计学意义（F=10.84、5.56、10.94、4.5、7.1、7.86，P<0.05）；注意/警觉性、词语学习和总分的交互效应有统计学意义（F=8.49、3.87、5.02，P<0.05），在第4、12周时，研究组在注意、词语学习和总分维度上得分均大于对照组（P<0.05），且得分高于基线（P<0.05）。结论 tACS治疗能够显著改善抑郁障碍患者的抑郁和焦虑情绪，并提升其认知功能。 |
| 英文摘要: |
| Background Cognitive function is closely related to an individual"s quality of life and social functioning. However, 20% to 35% of patients with depression continue to experience a certain degree of cognitive impairment even after their clinical symptoms have alleviated. Currently, it is believed that tACS treatment can improve depressive symptoms, but whether it can enhance cognitive function remains a subject of debate. Objective Exploring the effects of transcranial alternating current stimulation (tACS) treatment on the cognitive function of patients with depressive disorders.Methods This study recruited 49 patients with depressive disorders at the Fourth People"s Hospital of Wuhu City from November 2022 to October 2024. The participants were randomly divided into a study group (23 patients) and a control group (26 patients). Both groups received conventional sertraline treatment. The study group underwent transcranial alternating current stimulation (tACS) for 20 minutes, 5 times per week, for 4 consecutive weeks, while the control group received tACS stimulation with the same parameters for only 30 seconds. The Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, and a battery of cognitive tests were used to assess depressive symptoms, anxiety symptoms, and cognitive function at baseline, 4 weeks, and 12 weeks.Results There were no significant differences between the two groups in general demographic data such as gender, age, and education level. The HAMD and HAMA scales showed staTIStically significant time effects and interaction effects (F=260.43, 248.08; P<0.001). The HAMA also showed a significant group effect (F=4.5; P<0.05). At weeks 4 and 12, the study group had significantly lower HAMA scores than the control group (P<0.05). At week 12, the study group had significantly lower HAMD scores compared to the control group (P<0.01), and scores were significantly lower than baseline (P<0.01). Both groups demonstrated significant time effects in information processing speed, attention/alertness, working memory, verbal learning, visual learning, problem solving, and total scores (F=58.04, 70.33, 13.61, 27.88, 9.06, 8.15, 2.78, 51.67; P<0.01). Information processing speed, attention/alertness, verbal learning, visual learning, problem solving, and total scores showed significant group effects (F=10.84, 5.56, 10.94, 4.5, 7.1, 7.86; P<0.05). Attention/alertness, verbal learning, and total scores showed significant interaction effects (F=8.49, 3.87, 5.02; P<0.05). At weeks 4 and 12, the study group had higher scores than the control group in the dimensions of attention, verbal learning, and total scores (P<0.05), and scores were higher than baseline (P<0.05).Conclusion The combination of TIS and tACS treatment can significantly improve depressive and anxious symptoms in patients with depressive disorders and enhance their cognitive function. |
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