| Lei Mengyun,Du Yanhong,Gao Yao,Deng Huaili,Wang Binhong,Ren Zhiyong,Liu Sha,Causal relationship of liposomes and circulating metabolomes to schizophrenia： a two-step， two-sample Mendelian randomization study[J].SICHUAN MENTAL HEALTH,2025,(3):223-228 |
| Causal relationship of liposomes and circulating metabolomes to schizophrenia： a two-step， two-sample Mendelian randomization study |
DOI：10.11886/scjsws20241017001 |
| English keywords:Liposomes Circulating metabolomes Schizophrenia Mendelian randomization Mediation analysis |
| Fund projects:国家自然科学基金面上项目（项目名称：联合多模态EEG-fMRI探索磁惊厥对难治性精神分裂症额顶网络的调控机制，项目编号：82271546）；山西省留学人员科技活动择优资助项目（项目名称：rTMS辅助MST改善难治性精神分裂症认知障碍的神经机制研究，项目编号：20240041）；山西省科技创新人才团队（项目名称：重性精神障碍防治，项目编号：202304051001049）；2022年山西省回国留学人员科研资助项目（项目名称：联合多模态EEG-fMRI探索磁惊厥对难治性精神分裂症额顶网络的调控机制，项目编号：2022-190）；2024年度“六个一批”专项行动科研项目（项目名称：联合EEG-fNIRS探究MECT治疗对难治性精神分裂症疗效及其突显网络功能连接的影响，项目编号：Y2024008） |
|
| Hits: |
| Download times: |
| English abstract: |
| Background Schizophrenia is a complex， chronic and severe mental disorder， and the pathogenesis of which has not been fully elucidated. The abnormalities in lipid metabolism and circulating metabolomes have already been implicated in the pathophysiology of schizophrenia. However， available studies have mainly focused on a few liposomes and circulating metabolites， failing to systematically reveal the mediating role of circulating metabolomes in the causal relationship between liposomes and schizophrenia.Objective To uncover mediating role of circulating metabolomes in the causal relationship between liposomes and schizophrenia， thereby providing biomarkers and potential therapeutic targets for the prevention and treatment of schizophrenia.Methods Data from Genome-Wide Association Studies （GWAS） were analyzed， taking data on 179 liposomes as exposure variables， data on 123 circulating metabolites as intermediate variables， and data on schizophrenia as outcome variable. A two-step， two-sample Mendelian randomization analysis was conducted using the inverse-variance weighted （IVW）， MR- Egger， Weighted median， and Weighted mode methods to study the causal relationship of liposomes with schizophrenia and the mediating role of circulating metabolomes in the relationship.Results IVW model identified 8 lipids associated with schizophrenia without reverse causality. There were 5 circulating metabolomes strongly associated with schizophrenia. Acetate played a significant mediating role in the causal relationship between phosphatidylinositol （18：0_18：2） and schizophrenia （P=0.023， 95% CI： 0.036~0.532）， accounting for 28.4% of the causal relationship.Conclusion This study demonstrates a causal relationship between liposomes and schizophrenia， with phosphatidylinositol being a risk factor in the progression of schizophrenia， and acetate playing a mediating role in this process. ［Fund by National Natural Science Foundation of China General Program （number， 82271546）； Shanxi Merit Funding for Overseas Students Sci-Tech Activities Project （number， 20240041）； Shanxi Province Science and Technology Innovation Leading Talent Team Project （number， 202304051001049）； Shanxi Scientific Research Foundation for the Returned Overseas Chinese Scholars （number， 2022-190）； "Six Measures for Health Care Prosperity" Specialized Research Program （number， Y2024008）］ |
| View Full Text
View/Add Comment Download reader |
| Close |