He Yuqian,Wang Geman,Ran Rongting,Li Xuelian,Li Yujie,Deng Min,Zou Zhili,Research on the association between immune-related gene expression and panic disorder[J].SICHUAN MENTAL HEALTH,2025,(5):392-397

Research on the association between immune-related gene expression and panic disorder

DOI：10.11886/scjsws20250224003

English keywords:Panic disorder Gene expression Panic disorder severity scale Immune

Fund projects:四川省科技厅科技计划项目（项目名称：惊恐障碍全基因组甲基化分析及抗抑郁药对差异基因甲基化及其表达的动态机制研究，项目编号：2021YJ0440）

Author Name	Affiliation	Postcode
He Yuqian	School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China	610072
Wang Geman	School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China	610072
Ran Rongting	Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China Southwest Medical University, Luzhou 646000, China	646000
Li Xuelian	Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China North Sichuan Medical College, Nanchong 637000, China	637000
Li Yujie	Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China	610075
Deng Min	Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China North Sichuan Medical College, Nanchong 637000, China	637000
Zou Zhili^*	School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital （Affiliated Hospital of UESTC）, Chengdu 610072, China	610072

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English abstract:

Background Genetic factor plays an important role in the pathogenesis of panic disorder. Previous studies have revealed that immune system dysregulation is closely related to mental disorders such as panic disorder， while the relationship between panic disorder and immune-related gene expression remains unclear.Objective To explore the relationship between the expression of CXCL8， IL6R， JUN， PTGS2， TGFBR1， TLR2， CCR4 genes and panic disorder， providing references for the diagnosis and treatment of panic disorder.Methods A total of 52 patients who met the diagnostic criteria for panic disorder according to the Diagnosed and Statistical Manual of Mental Disorders， fourth edition （DSM-IV） were enrolled at the Psychosomatic Medicine Center of Sichuan Provincial People's Hospital from January 2020 to March 2021. Another 72 healthy individuals matched for age and gender from Chengdu were concurrently recruited as control group. The Panic Disorder Severity Scale （PDSS） was used to assess the severity of symptoms in panic disorder patients. Quantitative real-time polymerase chain reaction （PCR） was used to detect gene expression levels in two groups. Spearman correlation analysis was adopted to determine the correlation between PDSS score and immune-related gene expression in research group.Results The expression of the JUN， PTGS2 and TGFBR1 genes were significant higher in panic disorder patients than those in control group （Z=-4.172， -2.086， -3.018， P<0.05 or 0.01）. After false discovery rate （FDR） correction for multiple testing， the differential expression of JUN and TGFBR1 genes remained statistically significant between two groups （P<0.05）. There was no significant difference in the expression of CCR4， CXCL8， IL6R and TLR2 genes between two groups （P>0.05）. Correlation analysis revealed that the expression of the JUN gene in panic disorder patients was positively correlated with PDSS score （r=0.360， P<0.01）， while the CCR4， CXCL8， IL6R， PTGS2， TGFBR1 and TLR2 genes showed no statistically significant correlation with the PDSS score （P>0.05）.Conclusion The expression of the JUN and TGFBR1 genes may be associated with panic disorder， and the expression of the JUN gene correlated with the severity of panic disorder. ［Funded by Science and Technology Plan Project of Sichuan Provincial Department of Science and Technology （number， 2021YJ0440）］

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