| Zhu Yu,Zhang Shifei,Ye Hong,Bao Tianhao,Recent advances in pathophysiological mechanisms and treatment of post-stroke depression[J].SICHUAN MENTAL HEALTH,2025,(5):469-475 |
| Recent advances in pathophysiological mechanisms and treatment of post-stroke depression |
DOI：10.11886/scjsws20241224001 |
| English keywords:Post-stroke depression Pathophysiological mechanism Treatment |
| Fund projects:云南省科技厅科技计划项目（项目名称：miR-326-5p/LCN2信号轴在脑缺血预适应、后适应改善神经元调亡过程中的机制研究，项目编号：202101AY070001-048） |
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| Post-stroke depression （PSD） represents a common and debilitating complication following stroke， substantially impeding neurorehabilitation outcomes and exerting a profound negative impact on patients' quality of life， while concurrently contributing to increased mortality rates. Despite a growing understanding of PSD， contemporary clinical management continues to encounter multifaceted challenges. This systematic review synthesizes extant literature to delineate pathophysiological mechanisms underlying PSD and to identify evidence-based interventions. By establishing a theoretical foundation， it aims to optimize early diagnostic protocols and personalized therapeutic regimens， thereby enhancing rehabilitation and therapeutic outcomes in stroke patients. Through rigorous evaluation of 14 original studies， this analysis comprehensively examines genetic factors， neurobiological aberrations， immunological factors， and psychosocial stressors contributing to PSD onset and progression， offering critical insights for developing comprehensive treatment strategies.［Funded by Science and Technology Plan Project of Yunnan Provincial Department of Science and Technology （number， 202101AY070001-048）］ |
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