| Xu Lisi,Dai Caixia,Wan Shu,Liu Man,Cai Qingyan,Early-onset Alzheimer's disease comorbid with anti-N-methyl-D-aspartate receptor encephalitis： a case report[J].SICHUAN MENTAL HEALTH,2026,(2):171-174 |
| Early-onset Alzheimer's disease comorbid with anti-N-methyl-D-aspartate receptor encephalitis： a case report |
DOI：10.11886/scjsws20251201001 |
| English keywords:Anti-N-methyl-D-aspartate receptor encephalitis Alzheimer's disease Imaging manifestations Neuroinflammation |
| Fund projects:成都市医学科研课题（项目名称：基于静息态功能磁共振对伴妄想症状AD患者脑功能特征的探索性研究，项目编号：2024403） |
| Author Name | Affiliation | Postcode | | Xu Lisi | The Fourth People's Hospital of Chengdu, Chengdu 610036, China | 610036 | | Dai Caixia | The Fourth People's Hospital of Chengdu, Chengdu 610036, China | 610036 | | Wan Shu | The Fourth People's Hospital of Chengdu, Chengdu 610036, China | 610036 | | Liu Man | The Fourth People's Hospital of Chengdu, Chengdu 610036, China | 610036 | | Cai Qingyan* | The Fourth People's Hospital of Chengdu, Chengdu 610036, China | 610036 |
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| English abstract: |
| This article reports a case of a male patient with anti-N-methyl-D-aspartate receptor （NMDAR） encephalitis comorbid with early-onset Alzheimer's disease （AD）. The patient presented with depression， hallucinations and delusions syndrome， and cognitive impairment， and was admitted to a psychiatric hospital. Through multidisciplinary consultation， the diagnosis was confirmed based on positive biological and pathological biomarkers. The patient's symptoms improved after receiving a therapeutic regimen comprising high-dose glucocorticoid therapy and psychiatric-related treatments. Based on relevant current research findings domestically and internationally， this article reviews the pathogenesis and clinical manifestations of early-onset AD and anti-NMDAR encephalitis， in order to enhance the discrimination ability of psychiatric specialists for such patients and improve the diagnosis and treatment level. ［Funded by Medical Research Project of Chengdu City （number， 2024403）］ |
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