| Li Ruhui,Zeng Jianfei,Wang Bing,Wang Qin,Zhang Ying,Research progress on the mechanisms linking and intervention of adolescent depression and lipid metabolism disorders[J].SICHUAN MENTAL HEALTH,2026,(2):175-182 |
| Research progress on the mechanisms linking and intervention of adolescent depression and lipid metabolism disorders |
DOI：10.11886/scjsws20251031003 |
| English keywords:Depression Adolescents Lipid metabolism Dyslipidemia Unsaturated fatty acids |
| Fund projects:广东省高水平临床重点专科（深圳市配套建设经费）资助（项目编号：SZGSP013）；深圳市科技计划项目（项目名称：深圳市精神心理疾病临床医学研究中心，项目编号：20210617155253001） |
| Author Name | Affiliation | Postcode | | Li Ruhui | 1Clinical College of Mental Health, Shenzhen University Health Science Center, Shenzhen 518000, China
2Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen 518000, China | 518000 | | Zeng Jianfei | 1Clinical College of Mental Health, Shenzhen University Health Science Center, Shenzhen 518000, China
2Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen 518000, China | 518000 | | Wang Bing | 1Clinical College of Mental Health, Shenzhen University Health Science Center, Shenzhen 518000, China
2Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen 518000, China | 518000 | | Wang Qin | 1Clinical College of Mental Health, Shenzhen University Health Science Center, Shenzhen 518000, China
2Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen 518000, China | 518000 | | Zhang Ying* | 1Clinical College of Mental Health, Shenzhen University Health Science Center, Shenzhen 518000, China
2Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen 518000, China | 518000 |
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| English abstract: |
| In recent years， the incidence of depression among adolescents has increased significantly， becoming a serious global public health problem. There is a close relationship between adolescent depression and lipid metabolism abnormalities. However， the mechanisms underlying this association have not been fully elucidated. This article provides a review of the mechanisms and interventions linking adolescent depression and lipid metabolism abnormalities， aiming to offer new ideas for interventions in adolescent depression. Using computerized searches of the China National Knowledge Infrastructure （CNKI）， Wanfang Data， PubMed， and Web of Science， studies on the mechanisms and interventions related to adolescent depression and lipid metabolism were collected， with the search period extending up to October 10， 2025. Two researchers independently conducted literature screening and extracted basic information from the included studies. A total of 12 original studies were included. The results indicate that adolescent depression is associated with certain lipid metabolites. Neurobiological factors， immune inflammation， oxidative stress， and gut microbiota imbalance play important roles in this association. In addition， lipid metabolites such as omega-3 polyunsaturated fatty acids （ω-3 PUFAs） have a significant ameliorating effect on adolescent depression. ［Funded by Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties （number， SZGSP013）； Shenzhen Science and Technology Program （number， 20210617155253001）］ |
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