| Yuan Jiaxuan,Guo Fei,Zhao Chen,Du Ailing,Chen Yongxin,Yang Shichang,Efficacy of modified Wendan Decoction combined with antipsychotic drugs in the treatment of schizophrenia and its impact on patients' cognitive function： a Meta-analysis[J].SICHUAN MENTAL HEALTH,2026,(2):183-192 |
| Efficacy of modified Wendan Decoction combined with antipsychotic drugs in the treatment of schizophrenia and its impact on patients' cognitive function： a Meta-analysis |
DOI：10.11886/scjsws20260320001 |
| English keywords:Wendan Decoction Antipsychotic drugs Schizophrenia Cognitive function Systematic review |
| Fund projects:河南省研究生教育改革与质量提升工程项目（项目名称：临床思维，项目编号：YJS2023AL060）；河南省高等学校重点科研项目计划（项目名称：理气导痰汤治疗以阴性为主的痰气郁结型精神分裂症的网络药理学和临床疗效研究，项目编号：24B320018；项目名称：温阳兴奋汤治疗精神分裂症的疗效评价和网络药理学机制研究，项目编号：25B310004） |
| Author Name | Affiliation | Postcode | | Yuan Jiaxuan | 1The Second Affiliated Hospital of Henan Medical University, Xinxiang 453002, China | 453002 | | Guo Fei | 1The Second Affiliated Hospital of Henan Medical University, Xinxiang 453002, China
2Xinxiang Key Laboratory of Integrated Western and Chinese Medicine for Neuropsychiatric Disorders, Xinxiang 453002, China | 453002 | | Zhao Chen | 1The Second Affiliated Hospital of Henan Medical University, Xinxiang 453002, China
2Xinxiang Key Laboratory of Integrated Western and Chinese Medicine for Neuropsychiatric Disorders, Xinxiang 453002, China | 453002 | | Du Ailing | 1The Second Affiliated Hospital of Henan Medical University, Xinxiang 453002, China
2Xinxiang Key Laboratory of Integrated Western and Chinese Medicine for Neuropsychiatric Disorders, Xinxiang 453002, China | 453002 | | Chen Yongxin | 1The Second Affiliated Hospital of Henan Medical University, Xinxiang 453002, China
2Xinxiang Key Laboratory of Integrated Western and Chinese Medicine for Neuropsychiatric Disorders, Xinxiang 453002, China | 453002 | | Yang Shichang* | 1The Second Affiliated Hospital of Henan Medical University, Xinxiang 453002, China
2Xinxiang Key Laboratory of Integrated Western and Chinese Medicine for Neuropsychiatric Disorders, Xinxiang 453002, China
3Clinical Medical Center of Traditional Chinese and Western Medicine for Psychiatric Disorders of Henan Medical University, Xinxiang 453002, China
4Henan Provincial Collaborative Innovation Center for the Prevention and Treatment of Mental Disorders, Xinxiang 453002, China | 453002 |
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| Background Schizophrenia， as a common chronic mental disorder， although second-generation antipsychotic drugs have shown significant efficacy in alleviating positive symptoms， the widespread cognitive dysfunction among patients remains a challenge in clinical treatment. Traditional Chinese medicine has unique advantages in the treatment of mental disorders. However， the current clinical research on the combination of Wendan Decoction and antipsychotic drugs for schizophrenia varies in quality， and there is a lack of systematic reviews evaluating its effects on cognitive improvement and safety.Objective To systematically evaluate the effects of modified Wendan Decoction combined with antipsychotic drugs on schizophrenia symptoms and cognitive improvement， providing evidence-based support for the clinical application of Wendan Decoction.Methods Literature searches were conducted in China National Knowledge Infrastructure （CNKI）， Wanfang Data， VIP Information， China Biomedical Literature Service System， China Clinical Trial Registry， PubMed， Web of Science， the Cochrane Library， and Embase to collect randomized controlled trials （RCTs） of modified Wendan Decoction combined with antipsychotic drugs for the treatment of schizophrenia. The search period was from the establishment of the databases to March 19， 2026. The quality of the included literature was evaluated using the Cochrane 6.3. Meta-analysis was performed using RevMan 5.3 software.Results A total of 11 studies were included， involving 1 130 patients with schizophrenia. Among them， 566 cases were in the study group （receiving modified Wendan Decoction combined with antipsychotic drugs）， and 564 cases were in the control group （receiving antipsychotic drugs only）. Meta-analysis showed that the effective rate of improvement in psychotic symptoms in the study group was higher than that in the control group （RR=1.21，95% CI： 1.15–1.27， P<0.01）. In terms of psychotic symptoms， the Positive and Negative Symptom Scale （PANSS） positive symptom score （MD=-3.69， 95% CI： -5.87–-1.51， P<0.01） and PANSS total score （MD=-9.20， 95% CI： -11.80–-6.59， P<0.01） of the study group were lower than those of the control group. In cognitive function assessments， the Mini-Mental State Examination （MMSE） score （MD=2.51， 95% CI： 1.33–3.68， P<0.01） and the Loewenstein Occupational Therapy Cognitive Assessment （LOTCA） score （MD=11.85， 95% CI： 2.55–21.15， P=0.010） of the study group were higher than those of the control group， and the Wisconsin Card Sorting Test （WCST） score was lower than that of the control group （MD=-9.34， 95% CI： -12.57–-6.11， P<0.01）. The levels of brain-derived neurotrophic factor （BDNF） （SMD=1.34， 95% CI： 0.63–2.05， P<0.01） and nerve growth factor （NGF） （MD=6.94， 95% CI： 4.00–9.89， P<0.01） of the study group were higher than those of the control group. In terms of safety， there was no statistically significant difference in the incidence of adverse reactions between the two groups （RR=0.60， 95% CI： 0.31–1.18， P=0.14）.Conclusion The modified Wendan Decoction combined with antipsychotic drugs may be more effective than antipsychotic drugs alone in improving positive symptoms and cognitive function in patients with schizophrenia， and it also exerts a favorable neurotrophic regulatory effect. ［Funded by Postgraduate Education Reform and Quality Improvement Project of Henan Province （number， YJS2023AL060）； Key Scientific Research Projects of Higher Education Institutions in Henan Province （number， 24B320018， 25B310004）］ |
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