| Zhang Mengting,Xie Min,Zhang Jiashuo,Ma Xiaoying,Wei Menghan,Yin Yubing,Chen Yang,Wu Yulu,Wang Qiang,Association of adverse childhood experiences with psychopathology， sleep， and cognitive function in children： the mediating role of putamen volume[J].SICHUAN MENTAL HEALTH,2026,(3):263-273 |
| Association of adverse childhood experiences with psychopathology， sleep， and cognitive function in children： the mediating role of putamen volume |
DOI：10.11886/scjsws20260117001 |
| English keywords:Adverse childhood experiences Children Psychopathology Sleep disturbances Neurocognitive function Putamen |
| Fund projects:国家自然科学基金青年科学基金项目（项目名称：童年创伤与基因交互效应损伤精神分裂症脑白质网络的机制研究，项目编号：82401763）；四川大学华西医院专职博士后研发基金项目（项目名称：儿童青少年期环境与精神分裂症丘脑皮层环路的相关性研究，项目编号：2023HXBH084） |
| Author Name | Affiliation | Postcode | | Zhang Mengting | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Xie Min | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Zhang Jiashuo | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Ma Xiaoying | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Wei Menghan | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Yin Yubing | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Chen Yang | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Wu Yulu | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 | | Wang Qiang* | Medical Health Center, West China Hospital, Sichuan University, Chengdu 610041, China | 610041 |
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| Background Adverse childhood experiences （ACEs） are strong predictors of psychopathology across the lifespan， exerting extensive adverse effects on physical and mental health during early development. While ACEs increase the risk of childhood psychopathology， sleep quality and impair cognitive function， the early neurobiological mechanisms mediating ACE-induced cognitive impairment remain unclear.Objective To explore the association between ACEs exposure and the risk of psychopathology， sleep disorders， and cognitive function， and to examine the mediating role of the putamen volume in the relationship between ACEs and cognitive function from a neurodevelopment perspective.Methods Data were obtained from the Adolescent Brain Cognitive Development （ABCD） study， comprising 10 572 children aged 9 to 10. Participants were categorized into five groups based on the cumulative score of ACEs reported by their parents and the children themselves： no-exposure group （0 types of ACEs）， the one-exposure group， the two-exposure group， the three-exposure group， and the high-risk exposure group （≥ 4 types of ACEs）. Logistic regression analysis was employed to evaluate the association between ACEs and psychopathological symptoms ［T score of the Child Behavior Checklist （CBCL） ≥ 65］. Multiple linear regression analysis was ultilized to analyze the correlations between ACEs and the scores of the Sleep Disturbance Scale for Children （SDSC）， the NIH Toolbox Cognition Battery （NIHTB-CB）， as well as the multiple structures in the cerebral cortex and subcortex. The Bootstrap method was applied to test the mediating effect of the putamen volume between ACEs and neurocognitive function.Results After adjusting for confounders， ACEs cumulative score was correlated with children's psychopathological symptoms in a dose-response manner. Compared with the no-exposed group， the high-risk exposure group had a 2.08-fold （OR=2.080， 95% CI： 1.401–3.088） increased risk of internalizing problems and a 3.13-fold （OR=3.132， 95% CI： 1.703–5.760） increased risk of externalizing problems， and the risk of conduct problems was 4.68 times that of the no-exposed group （OR=4.681， 95% CI： 2.528–8.669）. ACEs cumulative score positively predicted the total score of SDSC （β=0.080， 95% CI： 0.059–0.102）， with relatively stronger predictive effects on sleep-wake transition disorder （β=0.086， 95% CI： 0.063–0.109） and sleep onset and maintenance disorder （β=0.066， 95% CI： 0.043–0.089）. In terms of neurocognition and brain structure， ACEs cumulative score negatively predicted the overall cognitive composite score （β=-0.025， 95% CI： -0.050–-0.001）， the crystallized cognitive composite score （β=-0.035， 95% CI： -0.060–-0.010）， the volume of the left putamen nucleus （β=-0.025， 95% CI： -0.046– 0.003）， and the volume of the right putamen nucleus （β=-0.023， 95% CI： -0.044– 0.003）. The total putamen volume played a partial mediating role between ACEs and the overall cognitive composite score， the effect value was -0.002 （95% CI： -0.004–-0.001）， accounting for 7.49% of the total effect.Conclusion ACEs exposure may increase the risk of psychopathological and sleep disturbances in children and may impair neurocognitive function. Reduced putamen volume may serve a potential neurobiological pathway underlying the impact of ACEs on childhood cognition. ［Funded by National Natural Science Foundation of China-Young Scientists Program （number， 82401763）； Sichuan University West China Hospital Full-time Postdoctoral Research and Development Fund Project （number， 2023HXBH084）］ |
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