| 【Abstract】 Objective To analyse quality of life in patients with depression and its associated factors, and to provide evidence for formulating the corresponding measures to improve the patients' quality of life. Methods A total of 117 inpatients who met the diagnostic criteria for depression of the International Classification of Diseases (10th Revision) (ICD-10) admitted to Zhanjiang Central People's Hospital, the Affiliated Hospital of Guangdong Medical University and Guangdong 999 Brain Hospital from 19th November 2018 to 7th September 2019 were enrolled in this study. The values of patients' clinical objective indicators including blood routine, urine routine, blood biochemical examination and blood gas analysis were collected from the medical records and all subjects were assessed using QLICD-DE (V2.0), a quality of life measurement scale for depressed patients. Simple correlation analysis was used to explore the correlation between the QLICD-DE (V2.0) scores and various clinical objective indicators, and multiple linear regression was used to further screen factors related to the quality of life of patients with depression. Results The results of simple correlation analysis showed that total protein and platelet distribution width were positively correlated with the total scores of quality of life in patients with depression (r=0.198, 0.281, P<0.05), while hematocrit was negatively correlated with it (r=-0.300, P<0.05). Multiple linear regression analysis showed that albumin/globulin and treatment compliance (B=-19.836, -3.711, P<0.05 or 0.01) were influential factors for physical function; platelet distribution width (B=2.706, P<0.01) was an influential factor in psychological function; bilirubin (B=-6.375, P<0.05) was an influential factor in social function; platelet distribution width (B=2.101, P<0.05) was an influencing factor for specific module; albumin/globulin and platelet distribution width (B=-10.653, 2.114, P<0.05 or 0.01) were influencing factors for total scores. Conclusion Treatment compliance and platelet distribution width, bilirubin and white/globulin in clinical objective indicators may be the influencing factors of quality of life in patients with depression.