|
| 精神分裂症合并肺结核患者用药监护1例 |
| Pharmaceutical Care for a Patient with Schizophrenia complicated with PulmonarySTuberculosis |
| 投稿时间：2022-05-07 修订日期：2022-11-22 |
| DOI： |
| 中文关键词: 精神分裂症 肺结核 氯氮平 利福平 |
| 英文关键词:Schizophrenia PulmonaryStuberculosis Clozapine Rifampicin |
| 基金项目:基金资助：广东省高水平临床重点专科（深圳市配套建设经费）资助（SZGSP013） |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 本文报道1例精神分裂症合并肺结核患者接受氯氮平600mg/d抗精神病联合利福平抗结核治疗，因利福平肝药酶诱导作用，氯氮平血药浓度无法达到有效浓度，患者仍存在被害妄想等精神症状，停用利福平后，氯氮平血药浓度在有效浓度范围内，且精神症状改善。通过精神分裂症合并肺结核患者治疗方案分析，本案例提示氯氮平联用利福平存在相互作用，以期为精神分裂症合并肺结核患者提供参考。 |
| 英文摘要: |
| This paper reported a case of schizophrenia complicated with pulmonary tuberculosis, 600 mg/d clozapine antipsychotic and rifampicin anti-tuberculosis treatment joint, clozapine blood drug concentration could not achieve effective concentration due to induction of liver drug enzyme of rifampicin. Stopping rifampicin, clozapine blood drug concentration in effective concentration, and significant improvement in psychotic symptoms achieved.Through the analysis of the treatment plan of schizophrenia patients with tuberculosis, this case suggests that there is an interaction between clozapine and rifampin, in order to provide a reference for schizophrenia patients with tuberculosis. |
| 查看/发表评论 下载PDF阅读器 |
| 关闭 |