| Objective To understand the association between depression, the degree of mental health knowledge and the attitude of mental illness among grassroots administrators, and to provide theoretical basis for further construction of mental health service and social psychological service system. Method The convenience sampling method was used to conduct a questionnaire survey In October 2020 among 690 residents' committee administrators, network staff and street office staff in Licheng District, Jinan. Information was collected by the general situation questionnaire, mental health knowledge questionnaire, mental health related attitude questionnaire and self-rating depression scale (SDS). To establish a regression model to explore the association between depression and the degree of mental health knowledge and the attitude of mental illness. Results The detection rate of depression (37.07%) of those grassroots administrators is statistically significant among the age (χ2=16.110), education level (χ2=18.949), marital status (χ2=8.611) and position (χ2=11.584). (P?0.05) In such personnel, the score of mental health knowledge was（15.20±2.77）, and the awareness rate was 75.99%.The attitude score of mental illness was (34.70±6.20). The degree of depression was negatively correlated with the scores of awareness questionnaire (r=-0.379, P?0.01), and positively correlated with the scores of attitude to mental illness (r=0.103, P=0.007). Multivariate analysis showed that the education level (b=0.660, 95% CL: 0.317-1.004, P?0.01) and the degree of depression (b=-1.231, 95% CL:-1.525-0.937, P?0.01) were related to mental health. Conclusion Grassroots administrators with a high detection rate of depression. And the more depressed they are, the lower their scores of mental health knowledge questionnaire, but the attitude towards mental illness is more positive.