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| 线粒体动力学、神经炎症和精神分裂症之间的关系 |
| Relationship between mitochondrial dynamics, neuroinflammation and schizophrenia |
| 投稿时间：2022-07-21 修订日期：2022-12-04 |
| DOI： |
| 中文关键词: 精神分裂症，免疫炎症，线粒体，小胶质细胞 |
| 英文关键词:Schizophrenia Immune inflammation Mitochondria Microglia |
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| 中文摘要: |
| 本文目的是综述线粒体功能障碍与小胶质细胞炎症在精神分裂症相关的病理生理学中的研究进展，为精神分裂症的发病机制提供参考。精神分裂症是一种严重的精神疾病，免疫炎症途径被认为是精神分裂症主要的发病机制之一，表现为脑内小胶质细胞激活和炎症因子水平升高。然而，导致精神分裂症免疫紊乱的生物学机制尚未完全阐明。越来越多的证据表明线粒体功能障碍可能在精神分裂症的发病机制中起关键作用。本文就线粒体功能与小胶质细胞炎症在精神分裂症病理生理学中的研究进展作一综述。 |
| 英文摘要: |
| The purpose of this paper is to review the research progress of mitochondrial dysfunction and microglial inflammation in the pathophysiology of schizophrenia and to provide reference for the pathogenesis of schizophrenia. Schizophrenia is a serious mental disease. Immune inflammatory pathway is considered to be one of the main pathogenesis of schizophrenia, which is characterized by the activation of microglia and the increase of inflammatory factors in the brain. However, the biological mechanism of immune disorder in schizophrenia has not been fully elucidated. There is increasing evidence that mitochondrial dysfunction may play a key role in the pathogenesis of schizophrenia. This article reviews the research progress of mitochondrial function and microglial inflammation in the pathophysiology of schizophrenia. |
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